BI-4394 (BI4394)

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BI-4394 (BI4394) Suppliers list
Company Name: ShangHai Caerulum Pharma Discovery Co., Ltd.  
Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 15026964105
Email: 2881489226@qq.com
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 13301690235
Email: Sales@ATKchemical.com

BI-4394 (BI4394) manufacturers

  • MMP13-IN-3
  • MMP13-IN-3 pictures
  • $89.00
  • 2026-07-27
  • CAS:1222173-37-6
  • Purity: 98.31%
  • Supply Ability: 10g
BI-4394 (BI4394) Basic information
Product Name:BI-4394 (BI4394)
Synonyms:BI-4394 (BI4394);MMP13-IN-3;inhibit,osteoarthritis,Inhibitor,MMP13 IN 3,Matrix metalloproteinases,MMP-13-IN-3,MMP13IN3,MMP,MMP-13;BI-4394;1H-Indole-2-carboxylic acid, 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-, 2-ethyl ester;MMP13-IN-3, 10 mM in DMSO;BI 4394 New;4-((5-(2-(Ethoxycarbonyl)-1H-indol-5-yl)-1-methyl-1H-pyrazole-3-carboxamido)methyl)benzoic acid
CAS:1222173-37-6
MF:C24H22N4O5
MW:446.46
EINECS:
Product Categories:
Mol File:1222173-37-6.mol
BI-4394 (BI4394) Structure
BI-4394 (BI4394) Chemical Properties
Boiling point 764.4±60.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (223.98 mM; ultrasonic and warming and heat to 60°C)
form A solid
pka4.16±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
BI-4394 (BI4394) Usage And Synthesis
UsesMMP13-IN-3 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor for the potential treatment of osteoarthritis and other related arthritic diseases.
in vivo

When dosed orally at 10 mg/kg or i.v. 1 mg/kg, BI-4394 (Compound 15) reaches micromolar plasma levels (AUC=1109±64 nM h/mL), displays modest clearance (CL=34 mL/min/kg), and shows acceptable bioavailability (39%). The Vss is quite low at 0.26 mL/mi/kg rat pharmacokinetic profile. BI-4394 has short terminal elimination half-life (t1/2=0.47 h for rat (1 mg/kg, i.v.) and rat (10 mg/kg, orally), respectively)[1].

Animal Model:Srapgue Dally Rats[1]
Dosage:10 mg/kg (oral gavage); 1 mg/kg (i.v.)
Administration:Dosed orally (10 mg/kg); i.v. (1 mg/kg)(Pharmacokinetic Analysis)
Result:T1/2=0.47 h for rat (1 mg/kg, i.v.) and rat (10 mg/kg, orally) , respectively.
IC 50MMP-13: 1 nM (IC50); MMP-14: 8.3 μM (IC50); MMP-9: 8.9 μM (IC50); MMP-10: 16 μM (IC50); MMP-2: 18 μM (IC50)
BI-4394 (BI4394) Preparation Products And Raw materials
Raw materials5-broMo-1-Methyl-1H-pyrazole-3-carboxylic acid-->Methyl 5-bromo-1-methyl-1H-pyrazole-3-carboxylate
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