BRD2492
(BRD 2492) manufacturers
- BRD2492
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- $30.00
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2026-06-09
- CAS:1821669-43-5
- Purity: 99.56%
- Supply Ability: 10g
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| | BRD2492
(BRD 2492) Basic information |
| Product Name: | BRD2492
(BRD 2492) | | Synonyms: | BRD2492
(BRD 2492);BRD2492;Benzamide, 4-(acetylamino)-N-[2-amino-5-(4-pyridinyl)phenyl]-;4-Acetamido-N-(2-amino-5-(pyridin-4-yl)phenyl)benzamide | | CAS: | 1821669-43-5 | | MF: | C20H18N4O2 | | MW: | 346.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1821669-43-5.mol |  |
| | BRD2492
(BRD 2492) Chemical Properties |
| Boiling point | 540.4±50.0 °C(Predicted) | | density | 1.321±0.06 g/cm3(Predicted) | | form | Solid | | pka | 12.81±0.70(Predicted) | | color | White to off-white |
| | BRD2492
(BRD 2492) Usage And Synthesis |
| Description | BRD2492 is a novel potent HDAC1/2 inhibitor. | | Uses | BRD2492 (compound 6d) is a potent, selective HDAC1 and HDAC2 inhibitor with IC50s of 13.2 nM and 77.2 nM, respecrtively. BRD2492 exhibits >100-fold selectivity for HDAC1/2 over selectivity over HDAC3 and HDAC6. BRD2492 inhibits breast cancer cell lines growth with IC50s of 1.01μM and 11.13μM for T-47D and MCF-7 cells, respectively[1]. | | IC 50 | HDAC1: 13.2 nM (IC50); HDAC2: 77.2 nM (IC50); HDAC3: 8908 nM (IC50); HDAC6: >1000 nM (IC50) | | References | [1] Linda Schker-Hübner, et al. Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors. ChemMedChem. 2022 May 4;17(9):e202100755. DOI:10.1002/cmdc.202100755 |
| | BRD2492
(BRD 2492) Preparation Products And Raw materials |
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