Tetrahydrofurfuryl bromide manufacturers
- Tetrahydrofurfuryl bromide
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- $15.00 / 1KG
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2021-08-12
- CAS:1192-30-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Tetrahydrofurfuryl bromide Basic information |
| | Tetrahydrofurfuryl bromide Chemical Properties |
| Boiling point | 170-171 °C (755 mmHg) | | density | 1.45 | | refractive index | 1.4853-1.4873 | | Fp | 63 °C | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Oil | | color | Clear Light Yellow | | BRN | 102717 | | InChI | InChI=1S/C5H9BrO/c6-4-5-2-1-3-7-5/h5H,1-4H2 | | InChIKey | VOHILFSOWRNVJJ-UHFFFAOYSA-N | | SMILES | O1CCCC1CBr | | CAS DataBase Reference | 1192-30-9(CAS DataBase Reference) | | EPA Substance Registry System | Furan, 2-(bromomethyl)tetrahydro- (1192-30-9) |
| Hazard Codes | Xi,Xn | | Risk Statements | 36/37/38-22 | | Safety Statements | 24/25 | | RIDADR | 1993 | | WGK Germany | WGK 3 | | RTECS | LU6000000 | | TSCA | TSCA listed | | HS Code | 29321900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 | | Toxicity | mouse,LD50,intravenous,180mg/kg (180mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03416, |
| | Tetrahydrofurfuryl bromide Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | (±)-Tetrahydrofurfuryl Bromide is a general chemical reagent used in the synthesis of tubulin polymerization inhibitors. | | Synthesis | In a 500-ml three-necked flask equipped with a stirrer, thermometer, dropping funnel, and calcium chloride tube, place 96 g of redistilled PBr₃ and 50 ml of dry benzene. Add 15 g of dry pyridine dropwise with stirring over 15 minutes.
Cool the flask in an ice-salt bath to -5°C. Then, slowly add a mixture of 102 g of tetrahydrofurfuryl alcohol and 5 g of dry pyridine over 4 hours, maintaining the internal temperature between -5° and -3°C. Stir for an additional hour and allow the mixture to warm to room temperature.
Let the mixture stand for 24-48 hours. Transfer it to a Claisen flask, rinse with a little benzene, and remove the benzene by distillation under reduced pressure (bath temperature ≤90°C). Finally, distill the product under high vacuum (5-10 mm Hg) with the bath temperature up to 150-155°C.
The crude product is redistilled to give pure tetrahydrofurfuryl bromide, boiling at 69-70°C/22 mm Hg. The yield is 90-102 g (53-61%)[1].
 | | References | [1] Org. Synth. 1943, 23, 88. DOI: 10.15227/orgsyn.023.0088. |
| | Tetrahydrofurfuryl bromide Preparation Products And Raw materials |
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