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LY310762

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LY310762 manufacturers

  • LY310762
  • LY310762 pictures
  • $29.00
  • 2026-07-15
  • CAS:192927-92-7
  • Purity: 99.80%
  • Supply Ability: 10g
  • LY310762
  • LY310762 pictures
  • $1.00
  • 2019-09-02
  • CAS:192927-92-7
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
  • LY310762
  • LY310762 pictures
  • $2.00
  • 2019-07-06
  • CAS:192927-92-7
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
LY310762 Basic information
Product Name:LY310762
Synonyms:1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride;CS-195;1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride;LY 310762 HCl;1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride;2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride;LY310762;LY-310762;3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
CAS:192927-92-7
MF:C24H27O2N2FHCl
MW:0
EINECS:
Product Categories:Inhibitors
Mol File:192927-92-7.mol
LY310762 Structure
LY310762 Chemical Properties
storage temp. Sealed in dry,Room Temperature
solubility DMSO: 10 mg/mL with heating, soluble
form white powder
color White to off-white
CAS DataBase Reference192927-92-7
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
LY310762 Usage And Synthesis
UsesLY-310762 Hydrochloride is a selective and potent SR-1D and 5-hydroxytryptamine (5-HT1D) receptor-preferring antagonist.
DefinitionChEBI: LY-310762 hydrochloride is a hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It contains a LY-310762(1+).
Biological Activity5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport.
in vivo

LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo[1].
LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model[2].

Animal Model:Dunkin Hartley guinea pigs (female; 350-400 g, Harlan)[1].
Dosage:10 mg/kg
Administration:Intraperitoneal injection; single
Result:Produced a further significant enhancement in the 5-HT response to fluoxetine.
Animal Model:Male Wistar rats (270-330 g; phenylephrine-infusion rats model)[2].
Dosage:1 mg/kg
Administration:Intravenous injection; single
Result:Completely abolished 5-HT vasodilator effects.
IC 505-HT1D Receptor: 249 nM (Ki)
storageroom temperature (desiccate)
LY310762 Preparation Products And Raw materials
Tag:LY310762(192927-92-7) Related Product Information
4-(4-Fluorobenzoyl)piperidine hydrochloride LY310762 Pimetine 4-(4-Fluorobenzyl)piperidine hydrochloride 2-(2-Furanyl)-7-[3-(4-methoxyphenyl)propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine L-Arginine, N-acetyl-L-phenylalanyl-L-ornithyl-L-prolyl-3-cyclohexyl-D-alanyl-L-tryptophyl-, (6→2)-lactam, trifluoroacetate (9CI)