- LY310762
-
- $29.00 / 5mg
-
2026-05-11
- CAS:192927-92-7
- Min. Order:
- Purity: 99.80%
- Supply Ability: 10g
- LY310762
-
- $1.00 / 1KG
-
2019-09-02
- CAS:192927-92-7
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
- LY310762
-
- $2.00 / 1kg
-
2019-07-06
- CAS:192927-92-7
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
|
| | LY310762 Basic information |
| Product Name: | LY310762 | | Synonyms: | 1-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]-3,3-dimethylindol-2-one,hydrochloride;CS-195;1-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-2H-indol-2-onehydrochloride;LY 310762 HCl;1-(2-(4-(4-fluorobenzoyl)piperidin-1-yl)ethyl)-3,3-diMethylindolin-2-one Hydrochloride;2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-diMethyl-, Monohydrochloride;LY310762;LY-310762;3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride | | CAS: | 192927-92-7 | | MF: | C24H27O2N2FHCl | | MW: | 0 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 192927-92-7.mol |  |
| | LY310762 Chemical Properties |
| storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: 10 mg/mL with heating, soluble | | form | white powder | | color | White to off-white | | CAS DataBase Reference | 192927-92-7 |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | LY310762 Usage And Synthesis |
| Uses | LY-310762 Hydrochloride is a selective and potent SR-1D and 5-hydroxytryptamine (5-HT1D) receptor-preferring antagonist. | | Definition | ChEBI: LY-310762 hydrochloride is a hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. It has a role as a receptor modulator and a serotonergic antagonist. It contains a LY-310762(1+). | | Biological Activity | 5-HT 1D -preferring receptor antagonist (EC 50 = 31 nM). Displays no activity on 5-HT transport. | | in vivo | LY310762 (10 mg/kg; i.p.; single) significantly increases the extracellular 5-HT concentration produced by Fluoxetine (selective serotonin re-uptake inhibitor) in vivo[1].
LY310762 (1 mg/kg; i.v.; single) abolishes 5-HT vasodilator effects in phenylephrine-infusion rats model[2]. | Animal Model: | Dunkin Hartley guinea pigs (female; 350-400 g, Harlan)[1]. | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; single | | Result: | Produced a further significant enhancement in the 5-HT response to fluoxetine. |
| Animal Model: | Male Wistar rats (270-330 g; phenylephrine-infusion rats model)[2]. | | Dosage: | 1 mg/kg | | Administration: | Intravenous injection; single | | Result: | Completely abolished 5-HT vasodilator effects. |
| | IC 50 | 5-HT1D Receptor: 249 nM (Ki) | | storage | room temperature (desiccate) |
| | LY310762 Preparation Products And Raw materials |
|