- Thiophene-3-ethanol
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- $10.00 / 1KG
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2026-01-05
- CAS:13781-67-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
- Thiophene-3-ethanol
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- $1.10 / 1g
-
2025-11-18
- CAS:13781-67-4
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons
- Thiophene-3-ethanol
-
- $0.00 / 1kg
-
2025-04-04
- CAS:13781-67-4
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
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| | Thiophene-3-ethanol Basic information |
| | Thiophene-3-ethanol Chemical Properties |
| Boiling point | 110-111 °C14 mm Hg(lit.) | | density | 1.144 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.552(lit.) | | Fp | 199 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 14.92±0.10(Predicted) | | form | Liquid | | color | Clear colorless to yellow-brown | | Specific Gravity | 1.144 | | Water Solubility | Sparingly soluble in water(0.059 g/L at 25°C). | | BRN | 107080 | | InChIKey | YYPNNBPPDFTQFX-UHFFFAOYSA-N | | LogP | 1.07 | | CAS DataBase Reference | 13781-67-4(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Thiopheneethanol(13781-67-4) |
| Safety Statements | 23-24/25 | | WGK Germany | 3 | | F | 10 | | HS Code | 29349990 |
| | Thiophene-3-ethanol Usage And Synthesis |
| Chemical Properties | Clear colorless to yellowish-brown liquid | | Uses | 3-Thiopheneethanol is used as a reagent in the synthesis of pH-responsive near-IR emitting conjugated polymer nanoparticles for cellular imaging and controlled-drug delivery. 3-Thiopheneethanol is also used as a reagent in the preparation of potent respiratory syncytial virus RNA polymerase inhibitors. | | Uses | 3-Thiopheneethanol [3-(2-hydroxyethyl)thiophene] was used in the synthesis of various ether and ester derivatives such as 3-(2-(benzyloxy)ethyl)thiophene, 3-[2-((triphenylmethyl)oxy)ethyl]thiophene, 3-[2-((trimethylsilyl)oxy)ethyl]thiophene, 3-[2-((dimethyl-tert-butylsilyl)oxy)ethyl]thiophene, 3-(2-acetoxyethyl)thiophene and 3-(2-(benzoyloxy)ethyl)thiophene. | | Synthesis | Step 2: Synthesis of 2-(thiophen-3-yl)ethanol
1. to LiAlH4 (4.56 g, 0.12 mol) was added tetrahydrofuran (200 mL) at 0 °C and the mixture was stirred.
2. Slowly add THF solution of 2-(thiophen-3-yl)acetic acid (14.2 g, 0.1 mol dissolved in 100 mL of THF) dropwise to the above mixture, keeping the temperature at 0 °C.
3. after the dropwise addition was completed, the reaction mixture was continued to be stirred at 0 °C for 2 hours.
4. EtOAc (200 mL) was slowly added to the reaction mixture followed by water (5 mL) to quench the reaction.
5. The resulting suspension was filtered through diatomaceous earth and the filtrate was dried with anhydrous sodium sulfate.
6. The dried filtrate was concentrated to dryness to give 2-(thiophen-3-yl)ethanol (12.44 g, yield: 99%).
7. The product was characterized by 1H NMR (MeOD, 400 MHz): δ 5.92-5.87 (m, 1H), 5.69-5.66 (m, 1H), 5.57 (s, 1H), 2.90 (d, J=14.0 Hz, 1H), 2.38 (d, J=14 Hz, 1H), 1.55-1.42 (m, 2H). | | References | [1] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148
[2] Synthesis, 2005, # 2, p. 267 - 271
[3] Synthesis (Germany), 2015, vol. 47, # 24, p. 3972 - 3982
[4] Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1994, vol. 256, p. 439 - 448
[5] Organic Process Research and Development, 2015, vol. 19, # 11, p. 1568 - 1575 |
| | Thiophene-3-ethanol Preparation Products And Raw materials |
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