- Azathramycin
-
- $1.00
-
2026-05-31
- CAS:76801-85-9
- Min. Order: 1g
- Purity: 0.99
- Supply Ability: 20 tons
- Azathramycin A
-
-
2026-05-29
- CAS:76801-85-9
- Min. Order: 1KG
- Purity: 90%min
- Supply Ability: 1000kg
- Azathramycin
-
-
2026-05-18
- CAS:76801-85-9
- Min. Order: 1kg
- Purity: 98%
|
| | Azathramycin Basic information |
| Product Name: | Azathramycin | | Synonyms: | Azithromycin EP Impurity A/(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-3,4,10-trihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy);(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,8,10,12,14-hexamethyl-1-oxa-6-azacyclopentadecan-15-one;Azithromycin Impurity P;Azathramycin
(Azaerythromycin A;Azithromycin EP Impurity A (Azathramycin) (Desmethyl Azithromycin);AZAERYTHROMYCIN A;DESMETHYL AZITHROMYCIN;Azithromycin Impurity 1（Azithromycin EP Impurity A）;DD-Azaerythromycin A | | CAS: | 76801-85-9 | | MF: | C37H70N2O12 | | MW: | 734.96 | | EINECS: | 616-385-9 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 76801-85-9.mol |  |
| | Azathramycin Chemical Properties |
| Melting point | 126-136°C | | Boiling point | 815.2±65.0 °C(Predicted) | | density | 1.18 | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | pka | 13.29±0.70(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic | | InChIKey | HRKNNHYKWGYTEN-HOQMJRDDSA-N | | LogP | 3.11 | | CAS DataBase Reference | 76801-85-9 |
| | Azathramycin Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | 9-Deoxo-9a-aza-9a-homo Erythromycin A (Azithromycin EP Impurity A) is a novel intermediate of Azithromycin that acts as antibiotic. | | Synthesis | Example-2; [93] [94] Preparation of 9-deoxy-9a-azo-9a-homoerythromycin A; Acetic acid was added dropwise to a methanolic (700 mL) suspension of 6,9-imino ether (II) (70.0 g), and the pH was adjusted to 5-6. Subsequently, an aqueous solution of PtO2 (7.0 g) was added to the above mixture and the reaction was carried out under a hydrogen pressure of 8-9 kg/cm2 and a temperature of 40-45°C for 4-5 hours for the hydrogenation reduction reaction. After completion of the reaction, the reaction mixture was filtered through Hyflo Super Cel and the filter cake was washed with methanol. The filtrates were combined and the methanol was removed by distillation under reduced pressure. To the residue, deionized water (700 mL) was added and the pH was adjusted to 11-12 with aqueous sodium hydroxide.The precipitated solid was filtered, drained, and dried in an oven to afford 9-deoxy-9a-azo-9a- homoerythromycin A(III) (55.0 g) in 85% yield. | | References | [1] Patent: WO2009/156938, 2009, A2. Location in patent: Page/Page column 8
[2] Patent: CN106632543, 2017, A. Location in patent: Paragraph 0003; 0025-0026
[3] Organic and Biomolecular Chemistry, 2008, vol. 6, # 22, p. 4120 - 4124
[4] Patent: CN106478541, 2017, A. Location in patent: Paragraph 0022; 0047 |
| | Azathramycin Preparation Products And Raw materials |
|