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| | Dichloro-1,2-dithiacyclopentenone Basic information |
| Product Name: | Dichloro-1,2-dithiacyclopentenone | | Synonyms: | Dichloro-1,2-dithiacyclopentenone in stock Factory;Dichloro-1,2-dihiacyclopenenone;4,5-dichloro(3H)-1,2-dithiol-2-one;2,2-Diphenyl-3-butynamide;4,5-dichlorodithiol-3-one;3H-1,2-Dithiol-3-one, 4,5-dichloro-;spectrum rx3127 and spectrum rx7844;4,5-Dichloro-1,2-
dithiacyclopentenone | | CAS: | 1192-52-5 | | MF: | C3Cl2OS2 | | MW: | 187.07 | | EINECS: | 214-754-5 | | Product Categories: | Heterocycle-other series;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Others;S-Containing | | Mol File: | 1192-52-5.mol |  |
| | Dichloro-1,2-dithiacyclopentenone Chemical Properties |
| Melting point | 52-56 °C | | Fp | 200 °C | | storage temp. | 2-8°C | | form | Solid | | BRN | 1342220 | | InChI | InChI=1S/C3Cl2OS2/c4-1-2(5)7-8-3(1)6 | | InChIKey | QGSRKGWCQSATCL-UHFFFAOYSA-N | | SMILES | S1C(Cl)=C(Cl)C(=O)S1 | | EPA Substance Registry System | 4,5-Dichloro-1,2-dithiacyclopentenone (1192-52-5) |
| Hazard Codes | T | | Risk Statements | 25-37/38 | | Safety Statements | 36/37/39-45 | | RIDADR | 2811 | | WGK Germany | 3 | | RTECS | JP1290000 | | HazardClass | 6.1(b) | | PackingGroup | III | | Toxicity | mouse,LD50,intravenous,13mg/kg (13mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#07423, |
| | Dichloro-1,2-dithiacyclopentenone Usage And Synthesis |
| Uses | 4,5-Dichloro-3H-1,2-dithiol-3-one (Dichloro-1,2-dithiacyclopentenone) is an E. coli FabH inhibitor (IC50: 2.9 μM). 4,5-Dichloro-3H-1,2-dithiol-3-one can be used as a slimicide in the manufacture of food-contact paper and paperboard [1][2]. | | Purification Methods | Dissolve it in CH2Cl2 (1g in 250ml), filter, wash it twice with H2O, evaporate and distil the residue in vacuo and then recrystallise it from pet ether. IR: max 1650 cm-1. [Boberg Justus Liebigs Ann Chem 679 109 1964, Boberg Justus Liebigs Ann Chem 693 212 1966, Beilstein 19/4 V 72.] | | References | [1] Song X, et al. Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitor. Chem Pharm Bull (Tokyo). 2014;62(11):1110-8. DOI:10.1248/cpb.c14-00485
[2] Mary S. Wolfe, et al. Chapter. National Toxicology Program. Book. Toxicology and Regulatory Process. 2006. Pages. 32 |
| | Dichloro-1,2-dithiacyclopentenone Preparation Products And Raw materials |
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