| Company Name: |
MQ (shanghai) Pharmaceuticals Co., Ltd.
|
| Tel: |
13761635123 |
| Email: |
sales@linyuepharm.com |
| Products Intro: |
Product Name:(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone , Ro 41-0960
CAS:125628-97-9
Purity:＞95% Package:1G，5G
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:Ro 41-0960
CAS:125628-97-9
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Ro 41-0960
CAS:125628-97-9
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
RO 41-0960 COMT IHIBITOR manufacturers
- Ro 41-0960
-
- $258.00 / 10mg
-
2026-01-04
- CAS:125628-97-9
- Min. Order:
- Purity:
- Supply Ability: 10g
|
| | RO 41-0960 COMT IHIBITOR Basic information |
| Product Name: | RO 41-0960 COMT IHIBITOR | | Synonyms: | RO 41-0960 COMT IHIBITOR;(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-methanon;(3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanone;or1139;RO 41-0960 COMT INHIBITOR;Methanone, (3,4-dihydroxy-5-nitrophenyl)(2-fluorophenyl)-;Ro 41-0960 solid;Ro 410960,Ro 41 0960 | | CAS: | 125628-97-9 | | MF: | C13H8FNO5 | | MW: | 277.2 | | EINECS: | | | Product Categories: | | | Mol File: | 125628-97-9.mol |  |
| | RO 41-0960 COMT IHIBITOR Chemical Properties |
| Melting point | 169-171°C | | storage temp. | 2-8°C | | solubility | H2O: <0.7 mg/mL, slightly soluble | | form | solid | | color | yellow | | Water Solubility | H2O: slightly soluble <0.7mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0mg/mL
ethanol: soluble | | InChI | 1S/C13H8FNO5/c14-9-4-2-1-3-8(9)12(17)7-5-10(15(19)20)13(18)11(16)6-7/h1-6,16,18H | | InChIKey | RQPAUNZYTYHKHA-UHFFFAOYSA-N | | SMILES | Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)c2ccccc2F |
| WGK Germany | 3 | | RTECS | PC4952300 | | Storage Class | 11 - Combustible Solids |
| | RO 41-0960 COMT IHIBITOR Usage And Synthesis |
| Uses | Ro 41-0960 has been used as an inhibitor of catechol-O-methyl-transferase in synaptosome membrane preparations and 3T3-L1 adipocytes. It has also been used as a catechol-O-methyl-transferase inhibitor to tre at corpus striatum samples to test its effect on dopamine metabolism. | | Preparation | preparation by demethylation of 2′-fluoro-4- hydroxy-3-methoxy-5-nitrobenzophenone with 48% hydrobromic acid in refluxing acetic acid for 4 h (86%). | | Biological Activity | Ro 41-0960 is a specific and synthetic inhibitor of the enzyme catechol-O-methyl-transferase (COMT). It binds to the catalytic site and triggers the inhibition of the methylation property of COMT. Ro 41-0960 is effective on uterine leiomyoma lesions and uterine fibroids. |
| | RO 41-0960 COMT IHIBITOR Preparation Products And Raw materials |
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