| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Email: |
sales8178@energy-chemical.com |
| Products Intro: |
Product Name:3,3′,5-Triiodo-L-thyronine sodiuM salt hydrate
CAS:345957-19-9
Purity:95% Package:100MG,250MG
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| Company Name: |
Guangzhou Isun Pharmaceutical Co., Ltd
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| Tel: |
020-39119399 18927568969 |
| Email: |
isunpharm@qq.com |
| Products Intro: |
Product Name:3,3',5-Triiodo-L-thyronine sodiuM salt hydrate
CAS:345957-19-9
Purity:95.0% Package:5Mg;25Mg;50Mg;250Mg;1g;2g;5g;25g
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3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& manufacturers
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| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Basic information |
| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Chemical Properties |
| Melting point | 205 °C (dec.)(lit.) | | storage temp. | Store at -20°C | | solubility | DMF: 0.25 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 1 mg/ml | | form | A crystalline solid | | color | white to light pink | | Optical Rotation | [α]22/D +21.5°, c = 2 in 1 N HCl: ethanol, 1:2 | | InChI | 1S/C15H12I3NO4.Na.H2O/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22;;/h1-4,6,12,20H,5,19H2,(H,21,22);;1H2/q;+1;/p-1/t12-;;/m0../s1 | | InChIKey | IRGJMZGKFAPCCR-LTCKWSDVSA-M | | SMILES | O.[Na+].N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C([O-])=O |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | Storage Class | 13 - Non Combustible Solids |
| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Usage And Synthesis |
| Description | 3,3'',5-Triiodo-L-thyronine (T3) is a thyroid hormone. It is produced by 5''-monodeiodination of the prohormone thyroxine (T4) in various tissues, including liver and kidney. T3 is an agonist of thyroid hormone receptors TRα and TRβ (Kis = 2.3 nM for both) that modulates diverse biological properties, including metabolism, cardiac function, growth, and redox signaling. It also functions as an inhibitor of L-type amino acid transporter 1 (LAT1), inhibiting LAT1-mediated leucine uptake in HEK293 cells when used at a concentration of 10 μM. | | Uses | Liothyronine sodium hydrate is an active form of thyroid hormone. Liothyronine sodium hydrate is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3]. | | IC 50 | Human Endogenous Metabolite | | References | [1] Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. DOI:10.1016/0304-3835(94)90274-7
[2] Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. DOI:10.1006/bbrc.1993.2055
[3] Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. DOI:10.1016/j.bmc.2012.03.056 |
| | 3 3' 5-TRIIODO-L-THYRONINE SODIUM SALT& Preparation Products And Raw materials |
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