| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532; 18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Salvinorin A
CAS:83729-01-5
Package:1mg, 5mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:Salvinorin A;(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-diMethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylicacidMethylester
CAS:83729-01-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Ascent Scientific
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| Tel: |
4401179829988 |
| Email: |
customerservice@ascentscientific.co.uk |
| Products Intro: |
Product Name:Salvinorin A;Divinorin A
CAS:83729-01-5
Purity:>99% Package:1mg;5mg Remarks:Potent κ agonist
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| | SALVINORIN A Basic information |
| Product Name: | SALVINORIN A | | Synonyms: | Salvinorin A solution;[2S-(2α,4aα,6aβ,7β,9β,10aα,10bβ)]-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-diMethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic Acid Methyl Ester;Salvinorin;2H-Naphtho[2,1-c]pyran-7-carboxylicacid, 9-(acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-,methyl ester, (2S,4aR,6aR,7R,9S,10aS,10bR)-;SALVINORIN A(P);(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester;(2S,4aR,6aR,7R,9S,10aS,10bR)-9-(Acetyloxy)-2-(3-furanyl)dodecahydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester;Divinorin A | | CAS: | 83729-01-5 | | MF: | C23H28O8 | | MW: | 432.46 | | EINECS: | 689-027-2 | | Product Categories: | Neurochcemicals;Agonist;Heterocycles;Opioids;Intermediates & Fine Chemicals;Pharmaceuticals;Opioid receptor and opioid-like receptor | | Mol File: | 83729-01-5.mol |  |
| | SALVINORIN A Chemical Properties |
| Melting point | 238-240° (Ortega); mp 242-244° (Valdes, 1984) | | alpha | D22 -45.3° (c = 8.530 in CHCl3); D25 -41° (c = 1 in CHCl3) | | Boiling point | 563.8±50.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | Fp | 2℃ | | storage temp. | −20°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | white | | Major Application | clinical testing | | InChIKey | OBSYBRPAKCASQB-AGQYDFLVSA-N | | SMILES | COC(=O)[C@@H]1C[C@H](OC(C)=O)C(=O)[C@H]2[C@@]1(C)CC[C@H]3C(=O)O[C@@H](C[C@]23C)c4ccoc4 |
| | SALVINORIN A Usage And Synthesis |
| Description | Salvinorin A (Item No. 11487) is an analytical reference material categorized as a diterpene. It is a hallucinogen derived from S. divinorum that has been used in the traditional spiritual practices of the Mazatec Indians and as a recreational drug. This product is intended for research and forensic applications. | | Uses | Salvinorin A is a potent and selective kappa-opioid receptor agonist. Salvinorin A has been reported to be brain-penetrant and displays psychoactive properties; hallucinogen. | | Uses | Salvinorin A is a hallucinogenic derived from the S. divinorum plant used in traditional spiritual practices of the Mazatec Indians and now gaining popularity as a recreational drug. Unlike other hallucinogens, which mediate their effects through serotonin 5-HT2A receptors, salvinorin A is a potent, selective κ-opioid receptor agonist (Ki = 2.4 nM; EC50 = 1.8 nM). This product is intended for forensic and research applications.In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions. | | Uses | In traditional medicine, the leaves are used for divination and for treatment of anemia and excretory functions. | | Definition | ChEBI: A natural product found in Salvia divinorum. | | Biological Activity | Potent naturally occuring non-nitrogenous κ -opioid selective agonist that displays high affinity at both native (K i = 4.3 nM) and cloned (K i = 16 nM) κ -opioid receptors. Also exhibits allosteric modulation of μ -opioid receptor binding. Reported to be brain-penetrant and displays psychoactive properties. | | Biochem/physiol Actions | Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (Ki=4.3 nm) and cloned (Ki=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor. | | References | [1] BRYAN L ROTH. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 1: 11934-11939. DOI: 10.1073/pnas.182234399
[2] WAYNE W. HARDING. Salvinicins A (I) and B (II), New Neoclerodane Diterpenes from Salvia divinorum.[J]. ChemInform, 2005, 36 47. DOI: 10.1002/chin.200547181
[3] KENJI TSUJIKAWA . Determination of salvinorin A and salvinorin B in Salvia divinorum-related products circulated in Japan[J]. Forensic science international, 2008, 180 2: Pages 105-109. DOI: 10.1016/j.forsciint.2008.07.008
[4] THOMAS A. MUNRO . Standard protecting groups create potent and selective κ opioids: Salvinorin B alkoxymethyl ethers[J]. Bioorganic & Medicinal Chemistry, 2008, 16 3: Pages 1279-1286. DOI: 10.1016/j.bmc.2007.10.067
[5] NICHOLAS J MALCOLM. Mu-opioid receptor selective superagonists produce prolonged respiratory depression.[J]. iScience, 2023, 26 7: 107121. DOI: 10.1016/j.isci.2023.107121 |
| | SALVINORIN A Preparation Products And Raw materials |
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