Casein Kinase II Inhibitor IV Hydrochloride
| 中文名称 | Casein Kinase II Inhibitor IV Hydrochloride |
|---|---|
| 中文同义词 | 化合物 T10687L;化合物 CASEIN KINASE II INHIBITOR IV HYDROCHLORIDE |
| 英文名称 | Casein Kinase II Inhibitor IV Hydrochloride |
| 英文同义词 | Casein Kinase II Inhibitor IV Hydrochloride;Benzenepropanenitrile, 3-[2-[(3,4,5-trimethoxyphenyl)amino]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, hydrochloride (1:1) |
| CAS号 | 2320347-54-2 |
| 分子式 | C24H23N5O3.ClH |
| 分子量 | 465.93 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2320347-54-2.mol |
| 结构式 |  |
Casein Kinase II Inhibitor IV Hydrochloride 性质
Target: Casein Kinase
Treatment of human epidermal keratinocytes (NHEKs) with Casein Kinase II Inhibitor IV leads to an increase in the early differentiation markers keratins 1 and 10 at 48 h. Increased levels of IVL and TGM are observed in cells treated with Casein Kinase II Inhibitor IV at 72 h and persisted at 96 h. In addition, treated with Casein Kinase II Inhibitor IV expresses loricrin, a terminal differentiation marker, at later time points. Similar results are observed by messenger RNA (mRNA) expression analysis of NHEKs treated with Casein Kinase II Inhibitor IV. At early time points (12 and 24 h), treatment with Casein Kinase II Inhibitor IV leads to the upregulation of keratinocyte early differentiation marker genes, including keratin 1 (5.4-fold) and keratin 10 (5.4-fold). Terminal differentiation marker genes, including IVL (1.8-fold), TGM 1 (4.8-fold), loricrin (3.3-fold), and filaggrin (5.6-fold), are upregulated at late time points (36 and 48 h). These results are consistent with the ability of Casein Kinase II Inhibitor IV to induce differentiation of epidermal progenitor cells into terminally differentiated keratinocytes.