Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]-

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Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- manufacturers
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Basic information
Product Name:Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]-
Synonyms:Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]-;SARS-CoV-2-IN-15
CAS:1580-42-3
MF:C14H9ClF3NO2
MW:315.67
EINECS:
Product Categories:
Mol File:1580-42-3.mol
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Structure
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Chemical Properties
Melting point 193-194 °C(Solv: ethanol (64-17-5))
Boiling point 338.2±42.0 °C(Predicted)
density 1.487±0.06 g/cm3(Predicted)
pka7.67±0.43(Predicted)
Safety Information
MSDS Information
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Usage And Synthesis
UsesSARS-CoV-2-IN-15 (compound 11) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.49 μM. SARS-CoV-2-IN-15 is a niclosamide analogue. SARS-CoV-2-IN-15 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
References[1] Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295. DOI:10.1016/j.ejmech.2022.114295
Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]- Preparation Products And Raw materials
Tag:Benzamide, 5-chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]-(1580-42-3) Related Product Information
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