Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]-

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Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- Suppliers list
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
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Products Intro: Product Name:PF-05381941
CAS:1474022-02-0
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:PF-05381941
CAS:1474022-02-0
Package:25mg;877USD|100mg;1820USD|50mg;1140USD
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +86-18327326525
Email: masar@topule.com
Products Intro: Product Name:PF-05381941
CAS:1474022-02-0
Purity:98% Package:100mg;1g;500g Remarks:Topule Company operates with integrity and has its own laboratory, which supports packaging and customization. Payment will be made after the product has passed third-party testing
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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Products Intro: Product Name:PF-05381941
CAS:1474022-02-0
Purity:0.98 Package:100mg;500mg;1g;5g Remarks:existing product
Company Name: Wuhan Jingkang en Biomedical Technology Co., Ltd
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Products Intro: Product Name:PF-05381941
CAS:1474022-02-0
Purity:0.98 Package:10G:100G

Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- manufacturers

  • PF-05381941
  • PF-05381941 pictures
  • $712.00
  • 2026-07-27
  • CAS:1474022-02-0
  • Purity: 98.04%
  • Supply Ability: 10g
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- Basic information
Product Name:Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]-
Synonyms:Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]-;PF 05381941,PF05381941;1-(3-(tert-Butyl)-1-(3-cyanophenyl)-1H-pyrazol-5-yl)-3-(3-methyl-4-(pyridin-4-yloxy)phenyl)urea
CAS:1474022-02-0
MF:C27 H26 N6 O2
MW:466.53
EINECS:
Product Categories:
Mol File:1474022-02-0.mol
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- Structure
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- Chemical Properties
Boiling point 561.0±50.0 °C(Predicted)
density 1.21±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (214.35 mM; Need ultrasonic)
form Solid
pka13.37±0.70(Predicted)
color Off-white to brown
Safety Information
MSDS Information
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- Usage And Synthesis
UsesPF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1].
IC 50p38α: 186 nM (IC50); TAK1: 156 nM (IC50)
References[1] Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505. DOI:10.1111/cbdd.12169
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- Preparation Products And Raw materials
Tag:Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]-(1474022-02-0) Related Product Information
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