Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem

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Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem manufacturers
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem Basic information
Product Name:Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem
Synonyms:Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem;N-Cyclohexyl-N?-dodecylurea, 1-Cyclohexyl-3?-dodecylurea, CDU;pressure,1 Cyclohexyl 3 dodecyl urea,epoxyeicosatrienoic,inhibit,Inhibitor,acid,1Cyclohexyl3dodecyl urea,antihypertensive,Epoxide Hydrolase,EET,blood;Urea, N-cyclohexyl-N'-dodecyl-;N-CYCLOHEXYL-N'-DODECYLUREA
CAS:402939-18-8
MF:C19H38N2O
MW:310.52
EINECS:
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Mol File:402939-18-8.mol
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem Structure
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem Chemical Properties
Boiling point 465.1±12.0 °C(Predicted)
density 0.92±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Ethanol: 16.67 mg/mL (53.68 mM)
form Solid
pka14.29±0.20(Predicted)
color White to off-white
Safety Information
MSDS Information
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem Usage And Synthesis
Uses1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension[1].
Biological ActivityCell permeable: yes', 'Primary Target
Soluble epoxide hydrolase', 'Product competes with ATP.', 'Reversible: no', 'Target IC50: 9.8 nM for mouse recombinant sEH, 85.2 nM for human recombinant sEH
in vivo

1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) (intraperitoneal injection; 3mg/day; 4 days) lowers systolic blood pressure by 30 mm Hg in Ang II hypertensive animals, whereas the corn oil vehicle has no effect on blood pressure in normotensive or Ang II hypertensive animals[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:3mg/day
Administration:Intraperitoneal injection; 4 days
Result:Had antihypertensive properties.
References[1] Imig JD,et al. Soluble epoxide hydrolase inhibition lowers arterial blood pressure in angiotensin II hypertension.Hypertension. 2002 Feb;39(2 Pt 2):690-4. DOI:10.1161/hy0202.103788
Soluble Epoxide Hydrolase Inhibitor, NCND - CAS 402939-18-8 - Calbiochem Preparation Products And Raw materials
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