| Company Name: |
GeneTex, Inc. |
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Company Name: |
NSJ Bioreagents |
| Tel: |
858.663.9055 8586639055 |
| Email: |
NSJBioname@qq.com |
| Company Name: |
Abmart Inc |
| Tel: |
4006-123-828 13162017139 |
| Email: |
market@ab-mart.com |
|
| | ABI3 antibody Chemical Properties |
| | ABI3 antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Abi1, Abi2, and Abi3 are members of the Abl1 interactor family, which function as adaptor signaling molecules downstream of the receptor tyrosine kinase Abl1. In addition to binding to Abl1, all Abi proteins contain a Src homology 3 domain and interact with the WAVE complex, an actin regulator involved in membrane ruffling and lamellipodia formation. As cytoskeletal adaptor proteins, Abi proteins are likely to regulate actin cytoskeletal remodeling. Interestingly, ABI3, the gene encoding Abi3, is genetically linked to Alzheimer’s disease. Abi3 may contribute to microglia-mediated AD progression by regulating microglial morphology. | | References | [1] Shi, Y. et al. (1995) Genes Dev 9, 2583-97.
[2] Dai, Z. and Pendergast, A.M. (1995) Genes Dev 9, 2569-82.
[3] Miyazaki, K. et al. (2000) Biochim Biophys Acta 1493, 237-41.
[4] Hirao, N. et al. (2006) FEBS Lett 580, 6464-70.
[5] Kotula, L. (2012) FEBS Lett 586, 2790-4.
[6] Conway, O.J. et al. (2018) Mol Neurodegener 13, 53.
[7] Sims, R. et al. (2017) Nat Genet 49, 1373-1384. |
| | ABI3 antibody Preparation Products And Raw materials |
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