| Company Name: |
GeneTex, Inc. |
| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Company Name: |
NSJ Bioreagents |
| Tel: |
858.663.9055 8586639055 |
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NSJBioname@qq.com |
| Company Name: |
Enzo Biochem Inc |
| Tel: |
Enzo Biochem Inc. 13797054060 |
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Enzoname@qq.com |
| Company Name: |
Biosynth Ltd |
| Tel: |
18886812933 |
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sales@biosynth.com |
|
| | CIITA antibody Chemical Properties |
| | CIITA antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | MHC class II proteins play critical roles in cellular immune responses and their expression is mainly regulated by the non-DNA binding transcription factor CIITA. CIITA expression is upregulated by IFN-γ and it in turn enchances MHC-II expression and represses collagen expression. CIITA has a limited number of transcriptional targets, most of which are involved in MHC-mediated antigen presentation. Mutations in the CIITA are associated with the hereditary immunodeficiency disease Bare Lymphocyte Syndrome which is characterized by a nearly complete absence of MHC-II expression. | | References | [1] Ting, J.P. and Trowsdale, J. (2002) Cell 109 Suppl, S21-33.
[2] Drozina, G. et al. (2005) Curr Top Microbiol Immunol 290, 147-70.
[3] Dong, Y. et al. (1999) J Immunol 162, 4731-9.
[4] Butticè, G. et al. (2006) Circ Res 98, 472-9.
[5] Krawczyk, M. et al. (2008) PLoS Genet 4, e1000058.
[6] Reith, W. and Mach, B. (2001) Annu Rev Immunol 19, 331-73.
[7] Waldburger, J.M. et al. (2000) Immunol Rev 178, 148-65. |
| | CIITA antibody Preparation Products And Raw materials |
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