| Company Name: |
CUSABIO TECHNOLOGY LLC
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| Tel: |
027-87196173 |
| Email: |
cusabio@163.com |
| Products Intro: |
Product Name:FOSB Antibody
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| Company Name: |
GeneTex, Inc.
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| Tel: |
0755-26755892 1-949-553-1900 |
| Email: |
international@genetex.com |
| Products Intro: |
Product Name:Fos B antibody
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| Company Name: |
NSJ Bioreagents
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| Tel: |
858.663.9055 8586639055 |
| Email: |
NSJBioname@qq.com |
| Products Intro: |
Product Name:FosB Antibody
|
| Company Name: |
Enzo Biochem Inc
|
| Tel: |
Enzo Biochem Inc. 13797054060 |
| Email: |
Enzoname@qq.com |
| Products Intro: |
Product Name:Fos B Antibody
|
| Company Name: |
Biosynth Ltd
|
| Tel: |
18886812933 |
| Email: |
sales@biosynth.com |
| Products Intro: |
Product Name:FOSB antibody
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| | FosB Antibody Chemical Properties |
| | FosB Antibody Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | The Fos family of nuclear oncogenes includes c-Fos, FosB, Fos-related antigen 1, and Fos-related antigen 2. While most Fos proteins exist as a single isoform, the FosB protein exists as two isoforms: full-length FosB and a shorter form, FosB2, which lacks the carboxy-terminal 101 amino acids. The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins to form Activator Protein-1, a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity. Phosphorylation of c-Fos at Ser32 and Thr232 by Erk5 increases protein stability and nuclear localization. Phosphorylation of FRA1 at Ser252 and Ser265 by Erk1/2 increases protein stability and leads to overexpression of FRA1 in cancer cells. Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate, but very short-lived, with protein levels dissipating after several hours. FRA1 and FRA2 expression persists longer, and appreciable levels can be detected in asynchronously growing cells. Deregulated expression of c-Fos, FosB, or FRA2 can result in neoplastic cellular transformation; however, Delta FosB lacks the ability to transform cells. | | References | [1] Tulchinsky, E. (2000) Histol Histopathol 15, 921-8.
[2] Dobrazanski, P. et al. (1991) Mol Cell Biol 11, 5470-8.
[3] Nakabeppu, Y. and Nathans, D. (1991) Cell 64, 751-9.
[4] Rosenberger, S.F. et al. (1999) J Biol Chem 274, 1124-30.
[5] Sasaki, T. et al. (2006) Mol Cell 24, 63-75.
[6] Basbous, J. et al. (2007) Mol Cell Biol 27, 3936-3950.
[7] Kovary, K. and Bravo, R. (1991) Mol Cell Biol 11, 2451-9.
[8] Kovary, K. and Bravo, R. (1992) Mol Cell Biol 12, 5015-23. |
| | FosB Antibody Preparation Products And Raw materials |
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