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| | Neuropeptide Y (D7Y5A) XP Rabbit mAb Chemical Properties |
| | Neuropeptide Y (D7Y5A) XP Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Neuropeptide Y is a 36 amino acid peptide that belongs to the pancreatic polypeptide family, which also includes peptide YY. The mature 36-residue NPY is produced from a larger pre-pro 97-residue NPY precursor through a series of cleavage reactions at dibasic sites and C-terminal amidation of the peptide product. NPY is widely expressed in the central nervous system and exerts its action through stimulation of 5 different receptors that belong to the G protein-coupled receptor family. NPY in the hypothalamus exhibits orexigenic activity through activation of Y1 and Y5 receptors. NPY is involved in the control of bone homeostasis, through the regulation of osteoblast activity by Y1 and Y2 receptors, and the regulation of testosterone secretion by activating Y1 receptor in testicular vessels. Research studies suggest that modulation of NPY activity and signaling represents a potential strategy for the development of appetite control and antiobesity agents. | | References | [1] Tatemoto, K. et al. (1982) Nature 296, 659-60.
[2] O'Hare, M.M. and Schwartz, T.W. (1989) Cancer Res 49, 7010-4.
[3] Adrian, T.E. et al. (1983) Nature 306, 584-6.
[4] Larhammar, D. and Salaneck, E. (2004) Neuropeptides 38, 141-51.
[5] Lin, S. et al. (2004) Neuropeptides 38, 189-200.
[6] Lee, N.J. and Herzog, H. (2009) Neuropeptides 43, 457-63.
[7] Allen, C.D. et al. (2011) Neuropeptides 45, 55-61.
[8] Simpson, K.A. et al. (2009) Arq Bras Endocrinol Metabol 53, 120-8. |
| | Neuropeptide Y (D7Y5A) XP Rabbit mAb Preparation Products And Raw materials |
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