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| | Spi-B (D3C5E) Rabbit mAb Chemical Properties |
| | Spi-B (D3C5E) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human | | Background | Spi-B belongs to the ETS family of transcription factors and activates transcription through direct binding to the PU box. Spi-B was identified based on its homology with PU.1/Spi-I. The function of Spi-B is most well studied in B cells and plasmacytoid dendritic cells. B cells from mice deficient in Spi-B proliferate poorly and die in response to signaling through the B cell receptor. In addition, Spi-B(-/-) mice have a defect in germinal center formation. Spi-B plays a role in both the development and function of pDCs. It is highly expressed by pDCs and not by monocyte-derived DCs, and overexpression of Spi-B in hematopoietic progenitor cells inhibits development of other lymphoid lineages. pDCs from Spi-B(-/-) mice produce less interferon in response to TLR7 and TLR9 stimulation and have lower expression of pDC-specific surface markers. Finally, Spi-B is required for differentiation of intestinal microfold cells. | | References | [1] Ray, D. et al. (1992) Mol Cell Biol 12, 4297-304.
[2] Su, G.H. et al. (1997) EMBO J 16, 7118-29.
[3] Schotte, R. et al. (2003) Blood 101, 1015-23.
[4] Sasaki, I. et al. (2012) Blood 120, 4733-43.
[5] Kanaya, T. et al. (2012) Nat Immunol 13, 729-6.
[6] de Lau, W. et al. (2012) Mol Cell Biol 32, 3639-47. |
| | Spi-B (D3C5E) Rabbit mAb Preparation Products And Raw materials |
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