P516-0475 manufacturers
- P516-0475
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- $1520.00
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2026-05-11
- CAS:1359627-33-0
- Purity:
- Supply Ability: 10g
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| | P516-0475 Basic information |
| Product Name: | P516-0475 | | Synonyms: | P516-0475;[1,2,3]Triazolo[1,5-a]quinoxaline-3-carboxamide, 4,5-dihydro-N-(3-methoxypropyl)-7-methyl-4-oxo- | | CAS: | 1359627-33-0 | | MF: | C15H17N5O3 | | MW: | 315.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1359627-33-0.mol |  |
| | P516-0475 Chemical Properties |
| density | 1.44±0.1 g/cm3(Predicted) | | pka | 11.05±0.20(Predicted) |
| | P516-0475 Usage And Synthesis |
| Description | P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture. | | Uses | P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2]. | | References | [1] Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293(3): 931-940. DOI:10.1074/jbc.M117.810994
[2] Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11(4):e0527922. DOI:10.1128/spectrum.05279-22 |
| | P516-0475 Preparation Products And Raw materials |
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