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| | Difenoconazole-d6 (hydrochloride) Basic information |
| | Difenoconazole-d6 (hydrochloride) Chemical Properties |
| solubility | Methanol: slightly soluble |
| | Difenoconazole-d6 (hydrochloride) Usage And Synthesis |
| Uses | Difenoconazole-d6 (hydrochloride) is deuterium labeled Difenoconazole. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth[1][2]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Mu X, et al. Evaluation of acute and developmental effects of difenoconazole via multiple stage zebrafish assays. Environ Pollut. 2013 Apr;175:147-57. DOI:10.1016/j.envpol.2012.12.029
[3] Dong F, et al. Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. Environ Sci Technol. 2013 Apr 2;47(7):3386-94. DOI:10.1021/es304982m
[4] E. REKANOVIĆ I P M Mihajlović. In vitro sensitivity of Fusarium graminearum (Schwabe) to difenoconazole, prothioconazole and thiophanate-methyl[J]. Pesticidi I Fitomedicina, 2010, 25 1: 325-333. DOI: 10.2298/pif1004325r
[5] L. L. VAWDREY D. W K R E Grice. Field and laboratory evaluations of fungicides for the control of brown spot (Corynespora cassiicola) and black spot (Asperisporium caricae) of papaya in far north Queensland, Australia[C]//37 6. 2008: 552-558. DOI: 10.1071/ap08055 |
| | Difenoconazole-d6 (hydrochloride) Preparation Products And Raw materials |
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