PKUMDL-LC-101-D04 manufacturers
- PKUMDL-LC-101-D04
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- $73.00
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2026-07-15
- CAS:2143896-83-5
- Purity: 99.65%
- Supply Ability: 10g
- PKUMDL-LC-101-D04
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-
2026-06-30
- CAS:2143896-83-5
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
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| | PKUMDL-LC-101-D04 Basic information |
| Product Name: | PKUMDL-LC-101-D04 | | Synonyms: | PKUMDL-LC-101-D04;GPX4-Activator-1d4;PKUMDL LC 101 D04,PKUMDL-LC-101-D-04,PKUMDLLC101D04;N-(2-aminoethyl)-4-[[(cyclopentylamino)thioxomethyl]amino]-benzenesulfonamide, monohydrochloride;N-(2-Aminoethyl)-4-(3-cyclopentylthioureido)benzenesulfonamide hydrochloride;PKUMDL-LC-101-D04 HCl;GPX4-Activator-1d4 Hydrochloride | | CAS: | 2143896-83-5 | | MF: | C14H23ClN4O2S2 | | MW: | 378.93 | | EINECS: | | | Product Categories: | | | Mol File: | 2143896-83-5.mol |  |
| | PKUMDL-LC-101-D04 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: soluble | | form | A crystalline solid | | color | White to off-white | | Water Solubility | H2O: 2mg/mL, clear | | InChIKey | FELDRJSFLBINQS-UHFFFAOYSA-N | | SMILES | S=C(NC1=CC=C(C=C1)S(NCCN)(=O)=O)NC2CCCC2.Cl |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | PKUMDL-LC-101-D04 Usage And Synthesis |
| Description | PKUMDL-LC-101-D04 is an allosteric activator of glutathione peroxidase 4 (GPX4).1 It increases GPX4 activity to 150% of control levels when used at a concentration of 20 μM in a cell-free assay and at 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts. PKUMDL-LC-101-D04 (200 μM) also reduces cholesterol hydroperoxide-induced MEF death. | | Uses | PKUMDL-LC-101-D04 (GPX4-Activator-1d4) is a glutathione peroxidase 4 (GPX4) allosteric activator (pEC50=4.7). PKUMDL-LC-101-D04 can inhibit ferroptosis and inflammation[1][2]. | | References | 1. Li, C., Deng, X., Zhang, W., et al. Novel allosteric activators for ferroptosis regulator glutathione peroxidase 4 J. Med. Chem. 62(1),266-275(2019). |
| | PKUMDL-LC-101-D04 Preparation Products And Raw materials |
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