2,5-Dihydroxycinnamic Acid phenethyl ester

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:5-LOX-IN-2
CAS:179691-97-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:5-LOX-IN-2
CAS:179691-97-5
Purity:99.18% Package:1mg;52USD|5mg;193USD|10mg;333USD
Company Name: Shanghai Beckham Medical Technology Co., Ltd  
Tel: 13816613772
Email: huahero21@sina.com
Products Intro: Product Name:5-LOX-IN-2
CAS:179691-97-5
Purity:98% HPLC Package:1g
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ：65489617 19372819560
Email: Sales@ATKchemical.com
Products Intro: CAS:179691-97-5
Purity:98 Package:1G,5G,10G,50G,100G,500G
Company Name: Shanghai Hongye Biotechnology Co. Ltd  
Tel: 400-9205774
Email: sales@glpbio.cn
Products Intro: Product Name:2,5-Dihydroxycinnamic Acid phenethyl ester
CAS:179691-97-5
Purity:>98% Package:1mg;10mg;50mg;100mg;

2,5-Dihydroxycinnamic Acid phenethyl ester manufacturers

  • 5-LOX-IN-2
  • 5-LOX-IN-2 pictures
  • $31.00
  • 2026-05-06
  • CAS:179691-97-5
  • Purity: 99.18%
  • Supply Ability: 10g
2,5-Dihydroxycinnamic Acid phenethyl ester Basic information
Product Name:2,5-Dihydroxycinnamic Acid phenethyl ester
Synonyms:2,5-Dihydroxycinnamic Acid phenethyl ester;2-Propenoic acid, 3-(2,5-dihydroxyphenyl)-, 2-phenylethyl ester, (2E)-;5-LOX-IN-2;(2E)-3-(2,5-dihydroxyphenyl)-2-propenoic acid, 2-phenylethyl ester;Phenethyl (E)-3-(2,5-dihydroxyphenyl)acrylate
CAS:179691-97-5
MF:C17H16O4
MW:284.31
EINECS:
Product Categories:
Mol File:179691-97-5.mol
2,5-Dihydroxycinnamic Acid phenethyl ester Structure
2,5-Dihydroxycinnamic Acid phenethyl ester Chemical Properties
Boiling point 515.5±50.0 °C(Predicted)
density 1.266±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form A crystalline solid
pka9.85±0.48(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
2,5-Dihydroxycinnamic Acid phenethyl ester Usage And Synthesis
Description2,5-Dihydroxycinnamic acid phenethyl ester is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 0.33 μM for inhibition of 5-LO product synthesis in polymorphonuclear leukocytes (PMNLs) stimulated with the sarcoendoplasmic reticulum calcium ATPase (SERCA) inhibitor thapsigargin .1 It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals (IC50 = 16.41 μM) in a cell-free assay. 2,5-Dihydroxycinnamic acid phenethyl ester selectively decreases viability of RCC4 and 786-O cells lacking the Von Hippel-Lindau (VHL) tumor suppressor gene (IC50s = 8 and 34.8 μM, respectively) over cells homozygously expressing VHL (IC50s = 99.6 and >100 μM, respectively). However, it also decreases viability of RCC10 VHL-/- and RCC10 VHL+/+ cells (IC50s = 5.04 and 0.96 μM, respectively). It increases the levels of pro-caspase-3a, LC3B-I, and LC3B-II in RCC4 VHL-/- cells in a concentration-dependent manner.
Uses5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research[1].
IC 505-LOX: 0.33 μM (IC50)
References1. Selka, A., Doiron, J.A., Lyons, P.A., et al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells Eur. J. Med. Chem. 179,347-357(2019).
2,5-Dihydroxycinnamic Acid phenethyl ester Preparation Products And Raw materials
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