- H-Asp(otbu)-otbu HCl
-
- $29.00 / 1g
-
2026-04-22
- CAS:1791-13-5
- Min. Order:
- Purity: 99.96%
- Supply Ability: 10g
- H-ASP(OTBU)-OTBU HCL
-
- $1.00 / 1KG
-
2019-07-06
- CAS:1791-13-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20kg
|
| | H-ASP(OTBU)-OTBU HCL Basic information |
| | H-ASP(OTBU)-OTBU HCL Chemical Properties |
| Melting point | 152-155 °C | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | soluble in Methanol | | form | Solid | | color | White to Almost white | | Optical Rotation | 10.6596°(C=1.0045g/100ml ETOH) | | BRN | 5652807 | | InChI | 1S/C12H23NO4.ClH/c1-11(2,3)16-9(14)7-8(13)10(15)17-12(4,5)6;/h8H,7,13H2,1-6H3;1H/t8-;/m0./s1 | | InChIKey | GVLZIMQSYQDAHB-QRPNPIFTSA-N | | SMILES | Cl.CC(C)(C)OC(=O)C[C@H](N)C(=O)OC(C)(C)C | | CAS DataBase Reference | 1791-13-5 |
| WGK Germany | 3 | | F | 10-21 | | HS Code | 29224999 | | Storage Class | 13 - Non Combustible Solids |
| | H-ASP(OTBU)-OTBU HCL Usage And Synthesis |
| Chemical Properties | White powder | | Uses | L-Aspartic acid di-tert-butyl ester hydrochloride may be used in neurological comparison studies with structurally similar compounds such as L-Glutamic acid di-tert-butyl ester. | | Biochem/physiol Actions | L-Aspartic acid di-tert-butyl ester hydrochloride may be used in neurological comparison studies with structurally similar compounds such as L-Glutamic acid di-tert-butyl ester (G7501). | | Synthesis | General procedure for the synthesis of di-tert-butyl (S)-2-aminosuccinate hydrochloride from Cbz-Asp(OtBu)-OtBu 18: Pd/C (10%, 830 mg, 10% w/w) was added to an ethanol solution of Cbz-Asp(OtBu)-OtBu 18 (8.25 g, 21.8 mmol) and ammonium formate (34.3 g, 0.54 mol). ) in an ethanol solution (20 mL). The suspension was stirred overnight at room temperature. Upon completion of the reaction, the suspension was filtered through diatomaceous earth and the solvent was removed under reduced pressure. The resulting residue was dissolved in ethyl acetate and the solution was cooled to 0°C. Subsequently, an ethyl acetate solution saturated with HCl was added dropwise and stirred for 15 minutes. The precipitated solid was filtered, washed with cold ethyl acetate and dried under vacuum to afford NH2-Asp(OtBu)-OtBu hydrochloride 16 (4.28 g, 17.4 mmol, 80% yield) as a white solid, which can be used in subsequent reactions without further purification. | | References | [1] Tetrahedron, 2014, vol. 70, # 44, p. 8343 - 8347 |
| | H-ASP(OTBU)-OTBU HCL Preparation Products And Raw materials |
|