| Company Name: |
Alfa Aesar |
| Tel: |
400-6106006 |
| Email: |
saleschina@alfa-asia.com |
| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
|
| | tert-Butylcarbamidine hydrochloride Basic information |
| Product Name: | tert-Butylcarbamidine hydrochloride | | Synonyms: | 2,2-DIMETHYLPROPANIMIDAMIDE HYDROCHLORIDE;2,2-DIMETHYLPROPIONAMIDINE HCL;2,2-DIMETHYL-PROPIONAMIDINEHYDROCHLORIDE;T-BUTYLCARBAMIDINE HYDROCHLORIDE;tert-ButylcarbamidineHCl;trimethylacetamidine hydrochloride;2,2,2-Trimethylacetamidine hydrochloride, 98%;Propanimidamide, 2,2-dimethyl-, hydrochloride (1:1) | | CAS: | 18202-73-8 | | MF: | C5H13ClN2 | | MW: | 136.62 | | EINECS: | 242-091-1 | | Product Categories: | pharmacetical;Aliphatics | | Mol File: | 18202-73-8.mol |  |
| | tert-Butylcarbamidine hydrochloride Chemical Properties |
| Melting point | 190 °C | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | powder to crystal | | color | White to Almost white | | Sensitive | Hygroscopic | | BRN | 3618865 | | InChIKey | ARDGQYVTLGUJII-UHFFFAOYSA-N | | CAS DataBase Reference | 18202-73-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | HazardClass | IRRITANT | | HS Code | 2921199990 |
| Provider | Language |
|
ALFA
| English |
| | tert-Butylcarbamidine hydrochloride Usage And Synthesis |
| Uses | Pivalimidamide Hydrochloride is used as a reagent in the preparation of 2-alkyl-4-aryltetrahydropyridopyrimidines and 2-alkyl-4-aryl-tetrahydropyrimidoazepines as selective 5-HT2A antagonists. | | Synthesis | Step (1) Preparation of tert-butylamidine hydrochloride: To a magnetically stirred mixed solution of 2,2-dimethyl-1-propanenitrile (25.0 g, 0.30 mol) and anhydrous methanol (26.8 mL, 0.79 mol) was added dropwise acetyl chloride (25 mL, 0.36 mol) and ether (30 mL) at 0 °C. After the dropwise addition, stirring was continued at 0 °C for 15 min. Subsequently, the reaction mixture was stirred at room temperature for 3 days. After completion of the reaction, white crystals were obtained by filtration, washed with ether and dried under vacuum. The dried crystals were mixed with an ethanol solution of 10% ammonia (150 mL, 0.90 mol) and stirred at room temperature for 3 days. The reaction mixture was filtered and the filtrate was concentrated to give a white solid. Recrystallization by ethanol gave a white crystalline product (18.9 g, 46% yield) with a melting point of 205°C (literature value 188°-190°C). NMR hydrogen spectrum (DMSO-d6): δ 1.22 (s, 9H), 8.63 (br d, 3H). | | References | [1] Patent: US4786640, 1988, A |
| | tert-Butylcarbamidine hydrochloride Preparation Products And Raw materials |
|