- 3-Bromo-5-chlorobenzonitrile
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- $200.00 / 1KG
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2025-09-25
- CAS:304854-55-5
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Bromo-5-chlorobenzonitrile Basic information |
| | 3-Bromo-5-chlorobenzonitrile Chemical Properties |
| Melting point | 70.7-71.1°C | | Boiling point | 144 °C / 12mmHg | | density | 1.74±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | soluble in Methanol | | form | powder to crystal | | color | White to Almost white | | InChI | InChI=1S/C7H3BrClN/c8-6-1-5(4-10)2-7(9)3-6/h1-3H | | InChIKey | DRKWKPSNVQVDKZ-UHFFFAOYSA-N | | SMILES | C(#N)C1=CC(Cl)=CC(Br)=C1 | | CAS DataBase Reference | 304854-55-5(CAS DataBase Reference) |
| | 3-Bromo-5-chlorobenzonitrile Usage And Synthesis |
| Uses | 3-Bromo-5-chlorobenzonitrile is the intermediate that is used for the new type anticancer medicine, belongs to the fine-chemical intermediate technical field. | | Synthesis | A solution of 1,3-dibromo-5-chlorobenzene (10 g, 37.34 mmol), pyridine (6.03 mL) and copper(I) cyanide (3.34 g, 37.34 ) in DMF (57.74 mL) was refluxed under nitrogen for 2 days.
mmol) in DMF (57.74 mL) was refluxed under nitrogen for 2 days. The reaction was difficult to monitor by TLC and when impurities were observed, the reaction was cooled to room temperature.
The reaction mixture was quenched with 40 mL of ether, the precipitate was filtered and washed with ether (20 mL x 2).
The organic layer was washed with a mixture of water and concentrated ammonium hydroxide (2:1, 40 mL), saturated ammonium chloride solution (40 mL x 2) and saturated sodium bicarbonate solution (40 mL). .
The organic layer was dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography to afford the compound 3-bromo-5-chlorobenzonitrile (2 g, 25%). |
| | 3-Bromo-5-chlorobenzonitrile Preparation Products And Raw materials |
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