| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:ACETOACETYL COENZYME A SODIUM SALT
CAS:102029-52-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Suzhou yacoo science co.,Ltd
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| Tel: |
0512-87182056 18013166090 |
| Email: |
lingling.qi@yacoo.com.cn |
| Products Intro: |
Product Name:Acetoacetyl coenzyme A sodium salt hydrate
CAS:102029-52-7
Purity:90% Package:10g;50g;1kg;5Kg;25kg;
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| | ACETOACETYL COENZYME A SODIUM SALT Basic information |
| Product Name: | ACETOACETYL COENZYME A SODIUM SALT | | Synonyms: | Coenzyme A,S-(3-oxobutanoate), tetrasodium salt (9CI);[5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[[3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[2-(3-oxobutanoylsulfanyl)ethylamino]propyl]amino]butoxy]-oxidophosphoryl]oxyphosphoryl]oxymethyl]oxolan-3-yl] phosphate;ACETOACETYL COENZYME A TRISODIUM SALT &;ACETOACETYL COENZYME A SODIUM;Acetoacetyl coenzyme A;coenzyme A acetoacetyl derivative trisodium salt hydrate;Acetoacetyl coenzyme A hydrate sodium salt;Acetoacetyl coenzyme A sodium salt hydrate,Acetoacetyl-CoANa3 | | CAS: | 102029-52-7 | | MF: | C25H37N7Na3O18P3S | | MW: | 917.55 | | EINECS: | | | Product Categories: | | | Mol File: | 102029-52-7.mol |  |
| | ACETOACETYL COENZYME A SODIUM SALT Chemical Properties |
| storage temp. | −20°C | | solubility | H2O: 50 mg/mL, clear, colorless to faintly yellow |
| | ACETOACETYL COENZYME A SODIUM SALT Usage And Synthesis |
| Uses | Acetoacetyl coenzyme A sodium is a central endogenous metabolite. The Km at pH 7.5 for Acetoacetyl coenzyme A sodium is 1.10 mM. Acetoacetyl coenzyme A sodium can be used for the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB)[1][2]. | | IC 50 | Microbial Metabolite | | Purification Methods | Purification can be carried out by passage through a DEAE-cellulose formate column, then through a Dowex 50 (H+) column to remove Na ions, concentrated by lyophilisation and redissolved in H2O. It is commercially available as a solution of 0.05g/mL of H2O. The concentration of acetoacetylcoenzyme A is determined by the method of Stern et al. [J Biol Chem 221 15 1956]. It is stable at pH 7-7.5 for several hours at 0o (half-life ca 1-2hours). At room temperature it is hydrolysed in ca 1-2hours at pH 7-7.5. At pH 1.0/20o it is more stable than at neutrality. A solution of the trisodium salt (0.05g/mL H2O) adjusted to pH 5 with 2N NaOH can be stored frozen for several weeks. It is stable at pH 2-3/-17o for at least 6 months. [Hersch & Jencks J Biol Chem 242 3468 1967, Clikenbeard et al. J Biol Chem 250 3108 1975, Simon & Shemin J Am Chem Soc 75 2520 1953, Moffatt & Khorana 81 1265 1959, Salem et al. Biochem J 258 563 1989, Beilstein 26 III/IV 3668.] | | References | [1] Thompson DK, et al. Purification and properties of an acetoacetyl coenzyme A-reacting phosphotransbutyrylase from Clostridium beijerinckii ("Clostridium butylicum") NRRL B593. Appl Environ Microbiol. 1990 Mar;56(3):607-13. DOI:10.1128/aem.56.3.607-613.1990
[2] Chohan SN, et al. Acetoacetyl coenzyme A reductase and polyhydroxybutyrate synthesis in rhizobium (Cicer) sp. Strain CC 1192. Appl Environ Microbiol. 1998 Aug;64(8):2859-63. DOI:10.1128/AEM.64.8.2859-2863.1998 |
| | ACETOACETYL COENZYME A SODIUM SALT Preparation Products And Raw materials |
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