- Y-27632
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- $31.00
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2026-05-11
- CAS:146986-50-7
- Purity: 99.72%
- Supply Ability: 10g
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| Product Name: | Y-27632 | | Synonyms: | ROCK INHIBITOR;(R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL;(R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE;(+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O;Y-27632;TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE;Y-276322HCl;4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride | | CAS: | 146986-50-7 | | MF: | C14H21N3O | | MW: | 247.34 | | EINECS: | 1312995-182-4 | | Product Categories: | Inhibitors;Protein Kinase;Signalling;Inhibitor;APIs;SiChem | | Mol File: | 146986-50-7.mol |  |
| | Y-27632 Chemical Properties |
| Melting point | >260°C (dec.) | | Boiling point | 462.6±15.0 °C(Predicted) | | density | 1.136±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,2-8°C | | solubility | H2O: 14 mg/mL | | form | solid | | pka | 13.53±0.40(Predicted) | | color | white | | Stability: | Hygroscopic | | InChI | InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1 | | InChIKey | IYOZTVGMEWJPKR-IJLUTSLNSA-N | | SMILES | [C@@H]1(C(NC2C=CN=CC=2)=O)CC[C@@H]([C@H](N)C)CC1 |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | Storage Class | 12 - Non Combustible Liquids |
| | Y-27632 Usage And Synthesis |
| Uses | Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor. | | Definition | ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti
ity against Rho-associated protein kinase (ROCK) enzyme. | | Biological Activity | Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation. | | in vivo | Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of myoclonic jerks when compare with saline group. Y-27632 (5 and 10 mg/kg) significantly prolongs the onset time of clonic convulsions when compare with saline group[3]. Treatment with Dimethylnitrosamine (DMN) causes a significant decrease in rat body and liver weight (DMN-S group) compared with control animals (S-S group). Oral Y27632 (30 mg/kg) essentially prevents this DMN-induced rat body and liver weight loss (DMN-Y group)[4]. | | IC 50 | ROCK-I: 220 nM (Ki); ROCK-II: 300 nM (Ki); PKN: 3.1 μM (Ki); Citron kinase: 5.3 μM (Ki); PKCα: 73 μM (Ki); PKA: 25 μM (Ki) | | Background | Y-27632 is a potent and selective ATP-competitive inhibitor of Rho-associated kinases, with Ki values of 0.22 µM and 0.30 µM for ROCK1 and ROCK2, respectively. In vitro kinase assays demonstrate that Y-27632 exhibits a 20-fold greater preference for ROCK when compared to citron kinase and protein kinase N. Research studies show that Y-27632 treatment of cells leads to inhibition of ROCK phosphorylation of myosin phosphatase subunit 1 at both Thr853 and Thr696, with a much greater inhibition of Thr853 phosphorylation. Y-27632 selectively inhibits smooth-muscle contraction by inhibiting Ca2+ sensitization. Additional research indicates that Y-27632 inhibits dissociation-induced apoptosis of cultured human embryonic stem cells over numerous passages and increases cloning efficiency. | | references | [1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83. |
| | Y-27632 Preparation Products And Raw materials |
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