- THIP HYDROCHLORIDE
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- $1.00 / 1kg
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2026-02-13
- CAS:64603-91-4
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
- THIP HYDROCHLORIDE
-
- $0.00 / 1kg
-
2026-01-19
- CAS:64603-91-4
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 10T
- THIP HYDROCHLORIDE
-
- $1.00 / 1KG
-
2025-12-12
- CAS:64603-91-4
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200000KG
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| | THIP HYDROCHLORIDE Basic information |
| Product Name: | THIP HYDROCHLORIDE | | Synonyms: | THIP HYDROCHLORIDE;4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3(2h)-onehydrate;4-c)pyridin-3(2h)-one,4,5,6,7-tetrahydro-isoxazolo(hydrate;gaboxadol;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL;4,5,6,7-TETRAHYDROISOXAZOLO[5,4-C]PYRIDIN-3-OL HYDROCHLORIDE;4,5,6,7-Tetrahydroisoxazolo[5,4-c]pyridin-3(2H)-one;THIP | | CAS: | 64603-91-4 | | MF: | C6H8N2O2 | | MW: | 140.14 | | EINECS: | 264-963-0 | | Product Categories: | GABA/Glycine receptor | | Mol File: | 64603-91-4.mol |  |
| | THIP HYDROCHLORIDE Chemical Properties |
| Melting point | 242-244° (dec) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | ethanol: 0.91 mg/mL | | form | solid | | pka | pKa (water, 25°): 4.44 ±0.03; 8.48 ±0.04 | | color | white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months. |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | RTECS | NY3396800 |
| | THIP HYDROCHLORIDE Usage And Synthesis |
| Description | Gaboxadol HCl (64603-91-4) is a GABA-A receptor agonist. Hypnotic agent. | | Uses | GABAa agonist, GABAc antagonist | | Definition | ChEBI: 4,5,6,7-Tetrahydroisoxazolo(5,4-c)pyridin-3-ol is an oxazole. | | Biological Activity | Systemically active GABA A receptor agonist and GABA C receptor antagonist. Displays antinociceptive, anticonvulsant and sedative effects. Hypnotic agent that enhances delta activity within non-REM sleep in rats. | | in vivo | THIP (Gaboxadol) (0.5, 5.0 mg/kg; p.o.; single) shws a good oral utilization, with Fa values of 110% and 83% for dosage of 0.5 and 5.0 mg/kg, respectively[2]. | Animal Model: | Sprague-Dawley rats (255-276 g)[2]. | | Dosage: | 2.5 mg/kg (for i.v.); 0.5 and 5.0 mg/kg (for p.o.). | | Administration: | Oral gavage; intravenous injection; single. | | Result: | 1.19Pharmacokinetic Parameters of THIP 4 in Sprague-Dawley rats[2].
| IV (2.5 mg/kg) | PO (0.5 mg/kg) | PO (5.0 mg/kg) | | AUC (ng/mLh) | 1193 | 263 | 1988 | | Tmax (h) | - | 0.22 | 0.33 | | Cmax (ng/mL) | 4350 | 291 | 2061 | | CL/Fa (mL/h/kg) | - | 1939 | 2558 | | CL (mL/h/kg) | 2043 | - | - | | Fa (%) | 100 | 110 | 83 |
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| | IC 50 | α4β3δ GABAAR: 13 μM (EC50) | | References | [1] PRATAP MEERA Thomas S O Martin Wallner. Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors.[J]. Journal of neurophysiology, 2011, 106 4: 2057-2064. DOI:10.1152/jn.00450.2011 |
| | THIP HYDROCHLORIDE Preparation Products And Raw materials |
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