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BOC Sciences |
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| | Misoprostol Acid Basic information |
| | Misoprostol Acid Chemical Properties |
| Boiling point | 538.3±50.0 °C(Predicted) | | density | 1.118±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Chloroform | | form | Yellow viscous oil. | | pka | 4.77±0.10(Predicted) | | color | Pale Yellow | | Stability: | Temperature Sensitive | | InChIKey | CNWGPXZGIIOYDL-MKYGPDKMSA-N | | SMILES | CCCCC(C)(O)C\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(O)=O |
| Hazard Codes | T | | Risk Statements | 45-60-61-25-36/37/38 | | Safety Statements | 53-22-36/37/39-45-26 | | RIDADR | UN 2810 6.1/PG 3 | | WGK Germany | 2 | | HazardClass | 6.1 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Eye Irrit. 2
Repr. 2
Skin Irrit. 2
STOT SE 3 |
| | Misoprostol Acid Usage And Synthesis |
| Description | Misoprostol is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid. | | Chemical Properties | Pale Yellow Gel | | Uses | Misoprostol Acid is a prostaglandin E1 analog with agonist activity mediated by EP2, EP3, and EP4 receptors. It has been shown to inhibit the formation of gastric lesions in rats (ED50 = 0.31 μg/kg), inhibit superoxide generation in human neutrophils (EC50 = 0.35 μM), and relax fetal rabbit ductus arteriosus (EC50 = 0.36 nM) in a concentration dependent manner. Misoprostol is commonly used in clinical medicine for the prevention of peptic ulcer disease. It has also been used in conjunction with mifepristone (RU-486; ) for the oral induction of first trimester abortion. Misoprostol contains a C-1 methyl ester and is readily absorbed and rapidly hydrolyzed in humans to the active free acid. | | Uses | A metabolite of Misoprostol. Cytoprotective PGE1 analog that prevents NSAID-induced gastric ulceration | | Uses | A cytoprotective prostaglandin PGE1 analogue. | | Biochem/physiol Actions | Misoprostol is a synthetic prostaglandin E1 (PGE1) analogue use to prevent non steroidal anti inflammatory drug-induced (NSAID) gastric ulcers; as a labor inducing and postpartum hemorrhage treatment agent. | | in vivo | Unlike the Misoprostol, Misoprostol acid is detectable in plasma. Misoprostol is a lipophilic methyl ester prodrug and is readily metabolized to the free acid, which is the biologically active form. Misoprostol is used worldwide for a variety of indications in obstetrics and gynecology. Misoprostol has both gastric antisecretory and mucosal protective effects[1]. | | IC 50 | EP | | References | [1] WALT R P. Misoprostol for the treatment of peptic ulcer and antiinflammatory-drug-induced gastroduodenal ulceration.[J]. New England Journal of Medicine, 1992, 327 22: 1575-1580. DOI: 10.1056/nejm199211263272207
[2] K T BUNCE. GR63799X–a novel prostanoid with selectivity for EP3 receptors.[J]. Advances in prostaglandin, thromboxane, and leukotriene research, 1991, 21A: 379-382.
[3] E. TALPAIN. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils[J]. British Journal of Pharmacology, 1995, 114 7: 1459-1465. DOI: 10.1111/j.1476-5381.1995.tb13370.x
[4] G C SMITH J C M R A Coleman. Characterization of dilator prostanoid receptors in the fetal rabbit ductus arteriosus.[J]. Journal of Pharmacology and Experimental Therapeutics, 1994, 271 1: 390-396.
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| | Misoprostol Acid Preparation Products And Raw materials |
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