- Ethyl 4-hydroxyphenylacetate
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- $15.00 / 1KG
-
2021-08-12
- CAS:17138-28-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Ethyl 4-hydroxyphenylacetate
-
- $15.00 / 1KG
-
2021-07-13
- CAS:17138-28-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | Ethyl 4-hydroxyphenylacetate Basic information |
| Product Name: | Ethyl 4-hydroxyphenylacetate | | Synonyms: | ETHYL 4-HYDROXYPHENYLACETATE;ETHYL-4-HYDROXYPHENYLACETIC ACID;4-HYDROXYPHENYLACETIC ACID ETHYL ETHER;4-Hydroxybenzeneacetic acid, ethyl ester;4-HYDROXYPHENYLACETIC ACID ETHYL ESTER 95%;2-(4-Hydroxyphenyl)acetic Acid Ethyl Ester;P-HYDROXYPHENYL ACETIC ACID ETHYL ESTER;4-hydroxy-benzeneaceticaciethylester | | CAS: | 17138-28-2 | | MF: | C10H12O3 | | MW: | 180.2 | | EINECS: | 241-197-5 | | Product Categories: | Aromatic Esters;Aromatics;Intermediates | | Mol File: | 17138-28-2.mol |  |
| | Ethyl 4-hydroxyphenylacetate Chemical Properties |
| Safety Statements | 22-24/25 | | TSCA | TSCA listed | | HazardClass | IRRITANT | | HS Code | 2916340000 |
| Provider | Language |
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ALFA
| English |
| | Ethyl 4-hydroxyphenylacetate Usage And Synthesis |
| Chemical Properties | Brown Semi-Solid | | Uses | Ethyl 4-hydroxyphenylacetate is a useful synthetic intermediate for the preparation of novel antiinflammatory agents. | | Synthesis | 4-Hydroxyphenylacetic acid (10.0 g, 65.7 mmol), anhydrous ethanol (120 mL), and concentrated hydrochloric acid (1 mL) were added to a round bottom flask. The reaction mixture was heated to reflux for 1 h and subsequently cooled to room temperature. The reaction mixture was neutralized in a small amount with saturated aqueous sodium bicarbonate solution. Most of the ethanol was evaporated under reduced pressure. The aqueous phase was extracted with ethyl acetate and the organic phase was sequentially washed well with water and dried with anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the target product ethyl p-hydroxyphenylacetate as an oil (11.8 g, 100% yield). The product was confirmed by NMR hydrogen spectrum (400 MHz, CDCl3): δ 7.13 (d, 2H), 6.76 (d, 2H), 5.10 (s, 1H), 4.15 (q, 2H), 3.36 (s, 2H), 1.26 (t, 3H). | | target | MAO | | References | [1] Patent: WO2006/20916, 2006, A2. Location in patent: Page/Page column 79
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 22, p. 8092 - 8105
[3] Synthesis, 2003, # 16, p. 2479 - 2482
[4] Patent: US2003/191181, 2003, A1. Location in patent: Page/Page column 10; 15
[5] Journal of Medicinal Chemistry, 1988, vol. 31, # 8, p. 1651 - 1656 |
| | Ethyl 4-hydroxyphenylacetate Preparation Products And Raw materials |
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