- Coptisine chloride
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- $95.00 / 10mg
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2026-03-05
- CAS:6020-18-4
- Min. Order:
- Purity: 99.42%
- Supply Ability: 10g
- Coptisine chloride
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- $0.00 / 20mg
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2023-02-24
- CAS:6020-18-4
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Coptisine chloride
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- $1.00 / 1kg
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2019-07-06
- CAS:6020-18-4
- Min. Order: 1g
- Purity: 99%
- Supply Ability: 100KG
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| | Coptisine chloride Basic information |
| Product Name: | Coptisine chloride | | Synonyms: | 2,3,9,10-BISMETHYLENEDIOXYPROTOBERBERINE;COPTISINE CHLORIDE;COPTISINE CHLORIDE(P);7,8,13,13a-Tetradehydro-2,3:9,10-bis(methylenedioxy)berbinium chloride;Coptisine Hcl;Coptisine Hydrochloride;COPTISINECHLORIDE(P)(PLEASECALL);6,7-Dihydrobis[1,3]benzodioxolo[5,6-a:4',5'-g]quinoliziniuM Chloride | | CAS: | 6020-18-4 | | MF: | C19H14ClNO4 | | MW: | 355.77 | | EINECS: | 611-948-5 | | Product Categories: | pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chemical reagent;Amines;Heterocycles;Inhibitor;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 6020-18-4.mol |  |
| | Coptisine chloride Chemical Properties |
| Melting point | >258°C (dec.) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | color | Orange to Dark Orange | | Stability: | Hygroscopic | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChI | InChI=1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1 | | InChIKey | LUXPUVKJHVUJAV-UHFFFAOYSA-M | | SMILES | C12=CC3=C(C4OCOC=4C=C3)C=[N+]1CCC1C=C3OCOC3=CC2=1.[Cl-] |
| WGK Germany | WGK 3 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Inhalation
Acute Tox. 2 Oral |
| | Coptisine chloride Usage And Synthesis |
| Chemical Properties | Orange Brown Solid | | Uses | Coptisine is an alkaloid found in Chinese goldthread (Coptis chinensis). A bacterial collagenase inhibitor. Coptisine has been found to reversibly inhibit Monoamine oxidase A in mice, pointing to a potential role as a natural antidepressant. | | in vivo | Coptisine shows increased toxicity in mice in a concentration dependent manner, with LD50 value of 880.18 mg/kg. Coptisine (154 mg/kg/day, 90 days) shows no toxicity on SD rats. Coptisine (23.35, 46.7, 70.05 mg/kg, p.o.) dose-dependently decreases the levels of TC, TG, and LDL-c and increases HDL-c content in serum of hamsters to different degree, slows down weight gain induced by the HFHC diet, and raises the level of cholesterol and TBA in feces dose-dependently in hamsters. Coptisine (70.05 mg/kg, p.o.) suppresses HMGCR protein expression level and induces the protein expression of SREBP-2, LDLR, and CYP7A1 involved in cholesterol metabolism[2]. | | IC 50 | IDO: 6.3 μM (IC50); IDO: 5.8 μM (Ki) |
| | Coptisine chloride Preparation Products And Raw materials |
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