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| | ANTI-CASPASE 6 Basic information |
| | ANTI-CASPASE 6 Chemical Properties |
| storage temp. | −20°C | | form | buffered aqueous solution | | biological source | rabbit |
| WGK Germany | WGK 1 | | Storage Class | 10 - Combustible liquids |
| | ANTI-CASPASE 6 Usage And Synthesis |
| Biological Activity | CASP6 (caspase 6) plays a key role in apoptosis, and cleaves proteins which contain (V/I/T/L)E(G/D)ID sites. It has two classes of substrate proteins- proteins involved in nuclear structure or function and intermediate filament proteins. Lamin A, B and C, DNA topoisomerase I, CBP/p300, nuclear death domain protein p84N5, nuclear matrix protein SATB1, emerin, NuMA, DFF40, and PARP etc. act as its substrates in nucleus. Chromatin condensation in apoptosis is a result of proteolysis of lamin A by CASP6. In cytoplasm, it acts upon desmin, vimentin and cytokeratin, thereby modulating cell structure and function. It is responsible for the degradation of axons in the primary cortex. It enhances the synthesis of amyloid β peptide (Aβ), and is highly expressed in the hippocampus and cortex in the brains of Alzheimerμs disease (AD) patients. CASP6 is also involved in the impairment of cognitive abilities in AD patients. |
| | ANTI-CASPASE 6 Preparation Products And Raw materials |
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