| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Company Name: |
Energy Chemical |
| Tel: |
021-58432009 400-005-6266 |
| Email: |
marketing@energy-chemical.com |
|
| | Cobinamide dicyanide Basic information |
| Product Name: | Cobinamide dicyanide | | Synonyms: | ETIOCOBALAMIN, FACTOR B;dicyanocobinamide;etiocobalamin;Dicyanocobinamide >=93%;Cobinamide dicyanide, Etiocobalamin, Factor B;Cobinamide dicyanide | | CAS: | 27792-36-5 | | MF: | C50H73CoN13O8 | | MW: | 1043.13 | | EINECS: | | | Product Categories: | | | Mol File: | 27792-36-5.mol |  |
| | Cobinamide dicyanide Chemical Properties |
| storage temp. | -20°C | | form | powder | | color | purple to very dark purple | | biological source | synthetic (organic) | | Merck | 13,3900 | | InChIKey | NJATWHPHZUGTHR-GXEWULDJSA-N |
| Hazard Codes | Xn | | Risk Statements | 68-22 | | Safety Statements | 36-37 | | WGK Germany | 3 | | F | 10 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | Cobinamide dicyanide Usage And Synthesis |
| Uses | Dicyanocobinamide has been used for the crystallization of vitamin B12-binding protein (BtuF). It has also been used for the destabilization of BtuCD-BtuF Interaction.', 'For use in determining non-intrinsic factor (R protein) in intrinsic factor preparations. | | Biological Activity | Dicyanocobinamide (Cbi) functions as a soluble guanylate cyclase (sGC) co-activator and targets the N-terminal regulatory regions. This action is similar to the effect of forskolin on adenylyl cyclases. Dicyanocobinamide elevates the intracellular cyclic guanosine monophosphate (cGMP) levels and exhibits vasorelaxant activity in rats. It is used along with various cobalamins in studies of the inhibition of HIV-1 integrase and nitric oxide synthase. |
| | Cobinamide dicyanide Preparation Products And Raw materials |
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