2-BENZYLOXY-5-BROMO-PYRIMIDINE manufacturers
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| | 2-BENZYLOXY-5-BROMO-PYRIMIDINE Basic information |
| | 2-BENZYLOXY-5-BROMO-PYRIMIDINE Chemical Properties |
| Melting point | 100-103°C | | Boiling point | 392.6±44.0 °C(Predicted) | | density | 1.499±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -0.21±0.22(Predicted) | | Appearance | Light yellow to yellow Solid | | CAS DataBase Reference | 742058-39-5 |
| | 2-BENZYLOXY-5-BROMO-PYRIMIDINE Usage And Synthesis |
| Uses | 2-(Benzyloxy)-5-bromopyrimidine is a pharmaceutical intermediate compound that can be used in the preparation of protein tyrosine phosphatase 2 (SHP2) inhibitors. | | Synthesis | Synthesis of 2-(Benzyloxy)-5-bromopyrimidine:
At room temperature, 5-bromo-2-chloropyrimidine (3.00 g, 15.51 mmol), benzyl alcohol (1.84 g, 17.06 mmol) and DMF (10 mL) were sequentially added to the flask. Potassium tert-butylate (2.82 g, 23.26 mmol) was added in portions. The mixture reacted at room temperature for 2 hours. Water was added, and the mixture was filtered to yield 2.10 g of the pure product, a yield of 51%. |
| | 2-BENZYLOXY-5-BROMO-PYRIMIDINE Preparation Products And Raw materials |
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