- 3-BROMO-4-HYDROXYBENZALDEHYDE
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- $8.00 / 1kg
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2025-09-25
- CAS:2973-78-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 3-BROMO-4-HYDROXYBENZALDEHYDE Basic information |
| | 3-BROMO-4-HYDROXYBENZALDEHYDE Chemical Properties |
| Melting point | 130-135 °C (lit.) | | Boiling point | 261.3±20.0 °C(Predicted) | | density | 1.737±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 6.24±0.18(Predicted) | | color | White to Pale Yellow | | Water Solubility | Soluble in water 1.33 g/L. | | Sensitive | Air Sensitive | | BRN | 2205318 | | InChI | InChI=1S/C7H5BrO2/c8-6-3-5(4-9)1-2-7(6)10/h1-4,10H | | InChIKey | UOTMHAOCAJROQF-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(O)C(Br)=C1 | | CAS DataBase Reference | 2973-78-6(CAS DataBase Reference) | | NIST Chemistry Reference | Benzaldehyde, 3-bromo-4-hydroxy-(2973-78-6) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29130000 |
| | 3-BROMO-4-HYDROXYBENZALDEHYDE Usage And Synthesis |
| Uses | 3-Bromo-4-hydroxybenzaldehyde is an intermediate in organic syntheses, it is used to produce other chemicals like 5-Brom-4-hydroxy-b-nitrostyrol. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 44, p. 3305, 1979 DOI: 10.1021/jo01333a006 | | Synthesis | General procedure for the synthesis of 3-bromo-4-hydroxybenzaldehyde from 2-bromo-4-methylphenol: A mixture of the substrate 2-bromo-4-methylphenol (1 mmol), cobalt salt (n1 mol%), and NaOH (n2 eq.) in ethylene glycol (5 mL) was stirred with oxygen (1 atm) and bubbled for 8 hr at 80 °C. Upon completion of the reaction, hydrochloric acid (10 mL, 2%) and methyl tert-butyl ether (MTBE, 10 mL) were added sequentially to the reaction mixture. The organic layer was separated and the aqueous phase was further extracted with MTBE (10 mL x 2). All organic phases were combined and concentrated by drying with anhydrous sodium sulfate to give the residue. The residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 10/1) to afford the target product 3-bromo-4-hydroxybenzaldehyde. | | References | [1] Tetrahedron Letters, 2014, vol. 55, # 8, p. 1406 - 1411
[2] Green Chemistry, 2014, vol. 16, # 5, p. 2807 - 2814
[3] Green Chemistry, 2014, vol. 16, # 3, p. 1248 - 1254
[4] Research on Chemical Intermediates, 2015, vol. 41, # 6, p. 3855 - 3863
[5] Journal of Molecular Catalysis A: Chemical, 2016, vol. 420, p. 45 - 49 |
| | 3-BROMO-4-HYDROXYBENZALDEHYDE Preparation Products And Raw materials |
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