| Company Name: |
Shenzhen Botel Biotechnology Co. Ltd.
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13316949107 13316968096 |
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1979313431@qq.com |
| Products Intro: |
Product Name:Alvimopan metabolite (ADL08-0011),hydrochloride salt
Purity:98% HPLC Package:10mg;25mg;50mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:ADL 08-0011 HCl
CAS:170098-43-8
Package:10mg/RMB 18900
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:ADL 08-0011 (hydrochloride)
CAS:170098-43-8
Purity:90% Package:1mg;5mg;10mg
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| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Basic information |
| Product Name: | Alvimopan metabolite (ADL08-0011),hydrochloride salt | | Synonyms: | Alvimopan metabolite (ADL08-0011),hydrochloride salt;Alvimopan Metabolite 1 (ADL 08-0011) HCl;Alvimopan Impurity 21;ADL 08-0011 (hydrochloride);(3R,4R)-1-((2S)-2-Benzyl-2-carboxyethyl)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidine hydrochloride | | CAS: | 170098-43-8 | | MF: | C23H30ClNO3 | | MW: | 403.95 | | EINECS: | | | Product Categories: | | | Mol File: | 170098-43-8.mol |  |
| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble,Methanol: soluble | | form | A solid |
| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Usage And Synthesis |
| Uses | Alvimopan metabolite hydrochloride is a peripherally restricted Opioid Receptor antagonist that inhibits the amplitude of electrically evoked contractions and spontaneous mechanical activity in guinea pig ileum[1]. | | Biological Activity | ADL 08-0011 is an active metabolite of the μ-opioid receptor antagonist alvimopan .1 It is produced from alvimopan via amide hydrolysis by gut microbiota. ADL 08-0011 is a μ-opioid receptor antagonist (Ki = 0.25 nM). It is selective for μ-opioid receptors over κ- and δ-opioid receptors (Kis = 15.8 and 31.6 nM, respectively). ADL 08-0011 inhibits endomorphin 1-induced inhibition of electrically induced contraction of isolated guinea pig ileum (pA2 = 9.4). In vivo, ADL 08-0011 (0.03-1 mg/kg) reverses loperamide-induced delayed gastric emptying in a rat model of castor oil-induced diarrhea.2 | | References | 1.Beattie, D.T., Cheruvu, M., Mai, N., et al.The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexoneNaunyn Schmiedebergs Arch. Pharmacol.375(3)205-220(2007)
2.Armstrong, S.R., Campbell, C.B., Richardson, C.L., et al.The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activityNaunyn Schmiedebergs Arch Pharmacol.386(6)471-478(2013) |
| | Alvimopan metabolite (ADL08-0011),hydrochloride salt Preparation Products And Raw materials |
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