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| | BRD-K98645985 Basic information |
| Product Name: | BRD-K98645985 | | Synonyms: | BRD-K98645985;BRD K98645985,BRD-K-98645985,BRDK98645985;Urea, N-(1-methylethyl)-N'-[(3S,6S,7R)-3,4,5,6,7,8,9,10-octahydro-7-methoxy-3,6,9-trimethyl-10-oxo-4-[[4-(2-pyridinyl)phenyl]methyl]-2H-1,4,9-benzoxadiazacyclododecin-12-yl]-;1-isopropyl-3-((3S,6S,7R)-7-methoxy-3,6,9-trimethyl-10-oxo-4-(4-(pyridin-2-yl)benzyl)-3,4,5,6,7,8,9,10-octahydro-2H-benzo[k][1,4,9]oxadiazacyclododecin-12-yl)urea | | CAS: | 1357647-78-9 | | MF: | C33H43N5O4 | | MW: | 573.73 | | EINECS: | | | Product Categories: | | | Mol File: | 1357647-78-9.mol |  |
| | BRD-K98645985 Chemical Properties |
| Boiling point | 699.4±55.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 13.73±0.46(Predicted) | | color | White to light brown |
| | BRD-K98645985 Usage And Synthesis |
| Definition | ChEBI: 1-[(4S,7S,8R)-8-methoxy-4,7,10-trimethyl-11-oxo-5-[[4-(2-pyridinyl)phenyl]methyl]-2-oxa-5,10-diazabicyclo[10.4.0]hexadeca-1(12),13,15-trien-14-yl]-3-propan-2-ylurea is an azamacrocycle and a lactam. | | Biological Activity | BRD-K98645985 is an inhibitor of BAF (mammalian SWI/SNF) transcriptional repression with EC50 of ~2.37 μM. It binds ARID1A-specific BAF complexes, prevents nucleosome localization, and potently reverses HIV-1 latency without T cell toxicity. | | in vitro | BRD-K98645985 (30 μM; 18 hours) treatment shows a 5-fold increase in Bmi1 , 2.6-fold increase in Ring1 , and 3.3- fold decrease in Fgf4 .
BRD-K98645985 treatment shows a concentration dependent latency reversal in J-Lat T-cell line models. BRD-K98645985 can be combined with other LRAs to improve reservoir targeting. | | target | | BAF transcriptional repression < span> 2.37 μM (EC 50 ) | HIV-1 | |
| | BRD-K98645985 Preparation Products And Raw materials |
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