NEO2734

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Company Name: BOC Sciences
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Products Intro: Product Name:NEO2734
CAS:2081072-29-7
Purity:98% Package:100 mg Remarks:Reach out to us for more information about custom solutions.
Company Name: TargetMol Chemicals Inc.
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Email: marketing@targetmol.com
Products Intro: Product Name:NEO2734
CAS:2081072-29-7
Purity:98.80% Package:1mg;116USD|5mg;289USD|10mg;478USD
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:NEO2734；EP31670
CAS:2081072-29-7
Package:1 mg；10 mg；100 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
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Email: tp@aladdinsci.com
Products Intro: Product Name:NEO2734
CAS:2081072-29-7
Purity:98% Package:$345.9/5mg;$573.9/10mg;$1291.9/25mg;$1632.9/50mg;Bulk package Remarks:98%
Company Name: Nanjing Chemlin Chemical Co., Ltd  
Tel: 025-83697070 13770331960
Email: info@chemlin.com.cn
Products Intro: Product Name:NEO2734; Neo 2734
CAS:2081072-29-7

NEO2734 manufacturers

  • NEO2734
  • NEO2734 pictures
  • $116.00 / 1mg
  • 2026-03-13
  • CAS:2081072-29-7
  • Min. Order:
  • Purity: 98.72%
  • Supply Ability: 10g
NEO2734 Basic information
Product Name:NEO2734
Synonyms:NEO2734;EP31670;NEO2734 (EP31670);PER-403,SPOP,NEO-2734,CBP,NEO 2734,MYC,HAT,NEO2734,Epigenetic Reader Domain,TC-797,Histone Acetyltransferase,p300,HATs,inhibit,Inhibitor,EP-31670,EP 31670;2(1H)-Pyridinone, 1,3-dimethyl-5-[2-(tetrahydro-2H-pyran-4-yl)-1-[2-(trifluoromethoxy)ethyl]-1H-benzimidazol-6-yl]-;NEO2734, 10 mM in DMSO;1,3-Dimethyl-5-(2-(tetrahydro-2H-pyran-4-yl)-1-(2-(trifluoromethoxy)ethyl)-1H-benzimidazol-6-yl)-2(1H)-pyridinone;NEO2734 ，S9648
CAS:2081072-29-7
MF:C22H24F3N3O3
MW:435.44
EINECS:
Product Categories:
Mol File:2081072-29-7.mol
NEO2734 Structure
NEO2734 Chemical Properties
Boiling point 598.0±50.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
solubility DMSO: Sparingly Soluble: 1-10 mg/ml
Ethanol: Sparingly Soluble: 1-10 mg/ml
form Solid
pka4.83±0.10(Predicted)
color White to off-white
Safety Information
MSDS Information
NEO2734 Usage And Synthesis
UsesNEO2734 (EP31670) is an orally active dual p300/CBP and BET bromodomain selective inhibitor, with IC50 values of <30 nM for both p300/CBP and BET bromodomains[1]. NEO2734 is active in SPOP mutant and wild-type prostate cancer[2].
in vivo

NEO2734 (5, 8, 10 mg/kg, orally) inhibits growth and prolongs survival in pre-clinical xenograft models[1].

Animal Model:Mice (PER-403 and 14169 models)[1].
Dosage:5, 8, 10 mg/kg
Administration:Orally, once daily for 28 days.
Result:Two of the three mice treated with NEO2734 were alive by day 100.
Provided markedly improved survival compared with EP, i-BET-762, and even iBET-762+EP by day 100 following initiation of treatment.
IC 50CBP/p300
References[1] Chevaun D Morrison-Smit, et al. Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734. Mol Cancer Ther. 2020 Jul;19(7):1406-1414. DOI:10.1158/1535-7163.MCT-20-0087
[2] Yuqian Yan, et al. The novel BET-CBP/p300 dual inhibitor NEO2734 is active in SPOP mutant and wild-type prostate cancer. EMBO Mol Med. 2019 Nov 7;11(11):e10659. DOI:10.15252/emmm.201910659
[3] De Souza, F.I., Zumiotti, A.V., and Da Silva, C.F. Neuregulins 1-α and 1-β on the regeneration the peripheral nerves[J]. Acta Ortop Bras.
NEO2734 Preparation Products And Raw materials
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