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BOC Sciences
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Product Name:PfDHODH-IN-1
CAS:183945-55-3
Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720 |
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klq@cw-bio.com |
| Products Intro: |
Product Name:PfDHODH-IN-1
CAS:183945-55-3
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
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010-60605840 18892239720 |
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psaitong@jm-bio.com |
| Products Intro: |
Product Name:PfDHODH-IN-1
CAS:183945-55-3
Purity:95% Package:100mg;250mg;500mg
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| Company Name: |
Zhejiang Huida Biotech Co., LTD
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0571-89903022 18679456698 |
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zilong@hizyme.com |
| Products Intro: |
Product Name:PfDHODH-IN-1
CAS:183945-55-3
Purity:>=98% Package:100mg；200mg
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| | PfDHODH-IN-1 Basic information |
| Product Name: | PfDHODH-IN-1 | | Synonyms: | PfDHODH-IN-1;antimalaria,PfDHODH IN 1,DNA/RNA Synthesis,Plasmodium,LDH,PfDHODH,Leflunomide,inhibit,Lactate Dehydrogenase,falciparum,PfDHODHIN1,Parasite,Inhibitor;2-Propenamide, 2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-;2-Cyano-3-cyclopropyl-3-hydroxy-N-(4-(trifluoromethyl)phenyl)acrylamide;PfDHODH-IN-1, 10 mM in DMSO | | CAS: | 183945-55-3 | | MF: | C14H11F3N2O2 | | MW: | 296.24 | | EINECS: | | | Product Categories: | | | Mol File: | 183945-55-3.mol |  |
| | PfDHODH-IN-1 Chemical Properties |
| Boiling point | 445.8±45.0 °C(Predicted) | | density | 1.488±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | solubility | DMSO : 83.33 mg/mL (281.29 mM; ultrasonic and warming and heat to 60°C) | | pka | 5.23±0.20(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | PfDHODH-IN-1 Usage And Synthesis |
| Uses | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity[1][2]. | | References | [1] Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. DOI:10.3390/ijms12052982
[2] Hou X, et al. QSAR study on the antimalarial activity of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. SAR QSAR Environ Res. 2016;27(2):101-24. DOI:10.1080/1062936X.2015.1134652 |
| | PfDHODH-IN-1 Preparation Products And Raw materials |
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