Tubulin inhibitor 6 manufacturers
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| | Tubulin inhibitor 6 Basic information |
| Product Name: | Tubulin inhibitor 6 | | Synonyms: | Tubulin inhibitor 6;iHAP1;Methanone, (2-chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)-;(2-Chloro-10H-phenothiazin-10-yl)(4-methoxyphenyl)methanone;DLD-1,cycle,K562,Tubulin inhibitor-6,tubulin,COLO-205,SKOV3,Tubulin inhibitor 6,451LU,Inhibitor,Microtubule/Tubulin,Tubulin inhibitor6,SW480,Antiproliferative,inhibit,NCIH460,BT549,cell;iHAP1
（Tubulin inhibitor 6）;(2-chlorophenothiazin-10-yl)-(4-methoxyphenyl)methanone;2-chloro-10-(4-methoxybenzoyl)-10H-phenothiazine | | CAS: | 105925-39-1 | | MF: | C20H14ClNO2S | | MW: | 367.85 | | EINECS: | | | Product Categories: | | | Mol File: | 105925-39-1.mol |  |
| | Tubulin inhibitor 6 Chemical Properties |
| Melting point | 155-157 °C | | Boiling point | 549.1±50.0 °C(Predicted) | | density | 1.364±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 62.5 mg/mL (169.91 mM) | | form | A crystalline solid | | pka | -5.56±0.20(Predicted) | | color | White to off-white | | InChIKey | CSWHYHPUEDNIQY-UHFFFAOYSA-N | | SMILES | S1c2c(cc(cc2)Cl)N(c4c1cccc4)C(=O)c3ccc(cc3)OC |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Tubulin inhibitor 6 Usage And Synthesis |
| Uses | Tubulin inhibitor 6 (Compound 14b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 6 inhibits tubulin polymerization with an IC50 of 0.87 μM. Tubulin inhibitor 6 inhibits K562 cell growth with an IC50 of 840 nM[1]. | | Biological Activity | Tubulin inhibitor 6 is an activator of protein phosphatase 2A (PP2A) enzymes that activates PP2A-B56ε and efficiently kills malignant cells. | | in vitro | Tubulin inhibitor 6 displays submicromolar antiproliferative activity. | | target | | Target | Value | PP2A
() | | References | [1] Prinz H, et al. N-benzoylated phenoxazines and phenothiazines: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. J Med Chem. 2011 Jun 23;54(12):4247-63. DOI:10.1021/jm200436t |
| | Tubulin inhibitor 6 Preparation Products And Raw materials |
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Tag:Tubulin inhibitor 6(105925-39-1)
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