Mal-NH-ethyl-SS-propionic acid manufacturers
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| | Mal-NH-ethyl-SS-propionic acid Basic information |
| Product Name: | Mal-NH-ethyl-SS-propionic acid | | Synonyms: | Mal-NH-ethyl-SS-propionic acid;Propanoic acid, 3-[[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethyl]dithio]-;3-((2-(3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido)ethyl)disulfaneyl)propanoic acid | | CAS: | 2128735-24-8 | | MF: | C12H16N2O5S2 | | MW: | 332.4 | | EINECS: | | | Product Categories: | | | Mol File: | 2128735-24-8.mol |  |
| | Mal-NH-ethyl-SS-propionic acid Chemical Properties |
| Boiling point | 638.5±50.0 °C(Predicted) | | density | 1.437±0.06 g/cm3(Predicted) | | solubility | Soluble in DMSO, DMF | | form | Solid | | pka | 4.25±0.10(Predicted) | | color | White to off-white |
| | Mal-NH-ethyl-SS-propionic acid Usage And Synthesis |
| Description | Mal-NH-ethyl-SS-propionic acid is a cleavabe, Maleimide linker. The maleimide group will react with thiol groups to form a covalent bond, enabling the connection of biomolecule to a thiol. Terminal carboxylic acids can react with primary amine groups using activators such as EDC and HATU to from stable amide bonds. | | Uses | Mal-NH-ethyl-SS-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | | IC 50 | Disulfide Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | Mal-NH-ethyl-SS-propionic acid Preparation Products And Raw materials |
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