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| | 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) Basic information |
| | 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) Chemical Properties |
| solubility | Soluble in DCM |
| | 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) Usage And Synthesis |
| Description | 2-(Azido-PEG3-amido)-1,3-bis(NHS Ester) is a branched PEGylation reagent. The azide groups enable PEGylation via Click Chemistry. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The PEG spacer allows for enhanced hydrophilic properties. | | Uses | 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Alkyl/ether | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | 2-(Azido-PEG3-amido)-1,3-bis(NHS ester) Preparation Products And Raw materials |
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