| Company Name: |
Zhengzhou Acme Chemical Co., Ltd.
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| Tel: |
0371-037163312495,13303845143 13303845143 |
| Email: |
3001379618@qq.com |
| Products Intro: |
Product Name:N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5
CAS:2226235-96-5
Purity:98% Package:1g;5g;25g
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| | N-PEG3-N'-(azide-PEG3)-Cy5 Basic information |
| | N-PEG3-N'-(azide-PEG3)-Cy5 Chemical Properties |
| solubility | Soluble in Water, DMSO, DMF, DCM |
| | N-PEG3-N'-(azide-PEG3)-Cy5 Usage And Synthesis |
| Description | N-(hydroxy-PEG2)-N'-(azide-PEG3)-Cy5 is a PEG linker containing a cyanine dye with excitation/emmission maximum 649/667 nm as well as an azide group, which enables Click Chemistry. The hydophilic PEG spacer increases solubility in aqueous media. | | Uses | N-PEG3-N'-(azide-PEG3)-Cy5 (chloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-PEG3-N'-(azide-PEG3)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | N-PEG3-N'-(azide-PEG3)-Cy5 Preparation Products And Raw materials |
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