Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-

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Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Basic information
Product Name:Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-
Synonyms:Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-
CAS:1186654-00-1
MF:C18H18F2N2O6S2
MW:460.47
EINECS:
Product Categories:
Mol File:1186654-00-1.mol
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Structure
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Chemical Properties
storage temp. 2-8°C
solubility DMSO: 50mg/mL
form powder
color white
InChI1S/C18H18F2N2O6S2/c19-14-2-1-3-15(20)18(14)30(25,26)22-8-6-21(7-9-22)29(23,24)13-4-5-16-17(12-13)28-11-10-27-16/h1-5,12H,6-11H2
InChIKeySHWNKRPMUBFWKE-UHFFFAOYSA-N
SMILESFC(C=CC=C1F)=C1S(N2CCN(S(C3=CC4=C(OCCO4)C=C3)(=O)=O)CC2)(=O)=O
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Usage And Synthesis
UsesA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
DefinitionChEBI: 1-(2,6-difluorophenyl)sulfonyl-4-(2,3-dihydro-1,4-benzodioxin-6-ylsulfonyl)piperazine is a sulfonamide.
Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]- Preparation Products And Raw materials
Tag:Piperazine, 1-[(2,6-difluorophenyl)sulfonyl]-4-[(2,3-dihydro-1,4-benzodioxin-6-yl)sulfonyl]-(1186654-00-1) Related Product Information