1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- manufacturers
- AD-2646
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- $1520.00
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2026-07-27
- CAS:366487-89-0
- Purity:
- Supply Ability: 10g
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| | 1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Basic information |
| | 1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Chemical Properties |
| Boiling point | 561.5±50.0 °C(Predicted) | | density | 1.056±0.06 g/cm3(Predicted) | | pka | 12.95±0.20(Predicted) |
| | 1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Usage And Synthesis |
| Uses | AD-2646 (LCL102), a ceramide analog, can kill leukemic T cells (EC50: 40 μM). AD-2646 triggers the cleavage of caspase-8, -9 and -3, as well as the caspase substrate PARP. AD-2646 is a ceramidase inhibitor. AD-2646 induces an accumulation of endogenous ceramide owing to perturbed ceramide metabolism[1][2]. | | IC 50 | Caspase-8; Caspase-9; Caspase 3 | | References | [1] Granot T, et al. Caspase-dependent and -independent cell death of Jurkat human leukemia cells induced by novel synthetic ceramide analogs. Leukemia. 2006 Mar;20(3):392-9. DOI:10.1038/sj.leu.2404084
[2] Fumiaki Tanaka, et al. In Vivo and In Vitro Inhibition of Human Cancer Cell Growth Using Adenoviral Vector Expressing FHIT Gene: Mechanism Analysis Using Microarray. Volume 7, Issue 5, Supplement S418-S419. May 2003. |
| | 1,3-Propanediol, 1-(4-nitrophenyl)-2-(tetradecylamino)-, (1R,2R)- Preparation Products And Raw materials |
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