|
|
| | H-Yc dehfc gamma-OH, cyclic Basic information |
| Product Name: | H-Yc dehfc gamma-OH, cyclic | | Synonyms: | KP7-6;L-Tyrosine, L-tyrosyl-L-cysteinyl-L-α-aspartyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-cysteinyl-, cyclic (2→7)-disulfide;H-Yc dehfc gamma-OH, cyclic | | CAS: | 629628-53-1 | | MF: | C48H56N10O15S2 | | MW: | 1077.15 | | EINECS: | | | Product Categories: | | | Mol File: | 629628-53-1.mol |  |
| | H-Yc dehfc gamma-OH, cyclic Chemical Properties |
| Boiling point | 1641.355±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.548±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | pka | 3.053±0.10(predicted) | | form | Solid | | color | White to off-white | | Sequence | Tyr-Cys-Asp-Glu-His-Phe-Cys-Tyr (Disulfide bridge:Cys2-Cys7) |
| | H-Yc dehfc gamma-OH, cyclic Usage And Synthesis |
| Uses | Kp7-6, a Fas mimetic peptide, is a Fas/FasL antagonist. Kp7-6 protects cells from Fas-mediated apoptosis, and protects mice from Fas-mediated hepatic injury[1][2]. | | References | [1] Zhang S, et al. Fas-associated death receptor signaling evoked by human amylin in islet beta-cells. Diabetes. 2008 Feb;57(2):348-56. DOI:10.2337/db07-0849
[2] Hasegawa A, et al. Fas-disabling small exocyclic peptide mimetics limit apoptosis by an unexpected mechanism. Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6599-604. DOI:10.1073/pnas.0401597101 |
| | H-Yc dehfc gamma-OH, cyclic Preparation Products And Raw materials |
|