1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-

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1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- manufacturers

  • SR-318
  • SR-318 pictures
  • $53.00
  • 2026-07-27
  • CAS:2413286-32-3
  • Purity: 99.74%
  • Supply Ability: 10g
  • SR-318
  • SR-318 pictures
  • $53.00
  • 2026-07-27
  • CAS:2413286-32-3
  • Purity: 99.74%
  • Supply Ability: 10g
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Basic information
Product Name:1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-
Synonyms:1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-;SR-318;anti-inflammatory,SR 318,TNFR,anti-cancer,p38 MAPK,Inhibitor,inhibit,whole,TNF Receptor,SR-318,SR318,p38α/β,Tumor Necrosis Factor Receptor,blood;SR-318, 10 mM in DMSO;5-Amino-N-(4-((3-cyclohexylpropyl)carbamoyl)benzyl)-1-phenyl-1H-pyrazole-4-carboxamide
CAS:2413286-32-3
MF:C27H33N5O2
MW:459.58
EINECS:
Product Categories:
Mol File:2413286-32-3.mol
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Structure
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Chemical Properties
Boiling point 732.0±60.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO:40.0(Max Conc. mg/mL);87.03(Max Conc. mM)
form A solid
pka13.10±0.46(Predicted)
color White to off-white
InChIKeyHXNUFFCHRIWTRZ-UHFFFAOYSA-N
SMILESNC1=C(C(NCC2=CC=C(C(NCCCC3CCCCC3)=O)C=C2)=O)C=NN1C4=CC=CC=C4
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Usage And Synthesis
UsesSR-318 is a potent and highly selective p38 MAPK inhibitor with IC50s of 5 nM, 32 nM and 6.11 μM for p38α, p38β and p38α/β, respectively. SR-318 potently inhibits the TNF-α release in whole blood with an IC50 of 283 nM. SR-318 has anti-cancer and anti-inflammatory activity[1].
Biological ActivitySR-318 is a potent and selective type-II inhibitor th at targets p38α/β in an inactive DFG-out conformation with good kinome selectivity (p38α/β IC50 = 5/39 nM by radiometric kinase assay). SR-318 selectively inhibits p38α/β by cell-based NanoBRET assay (IC50 = 3.7 nM/p38α, 10 nM/p38β, 0.91 μM/ZAK, ≥3 μM/DDR1, DDR2, KIT, MYLK4, RSK4) and effectively blocks LPS-induced TNF-α release in human whole blood (IC50 = 283 nM). SR-321 is an inactive structural analog and the recommended negative control compound.
IC 50p38α: 5 nM (IC50); p38β: 32 nM (IC50)
References[1] Rhm S, et al. Fast Iterative Synthetic Approach toward Identification of Novel Highly Selective p38 MAP Kinase Inhibitors. J Med Chem. 2019 Dec 12;62(23):10757-10782. DOI:10.1021/acs.jmedchem.9b01227
1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl- Preparation Products And Raw materials
Tag:1H-Pyrazole-4-carboxamide, 5-amino-N-[[4-[[(3-cyclohexylpropyl)amino]carbonyl]phenyl]methyl]-1-phenyl-(2413286-32-3) Related Product Information
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