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| | 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Basic information |
| Product Name: | 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID | | Synonyms: | 5-Bromo-4-methylpicolinic acid, 5-Bromo-2-carboxy-4-methylpyridine;5-BroMo-2-carboxy-4-Methylpyridine;5-bromo-4-methyl-2-Pyridinecarboxylic acid;5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID;5-broMo-4-Methylpicolinic acid;2-carboxylic acid-4-methyl-5-bromopyridine;2-Pyridinecarboxylic acid, 5-bromo-4-methyl-;5-bromo-4-methylpyridin-2-carboxylic acid | | CAS: | 886365-02-2 | | MF: | C7H6BrNO2 | | MW: | 216.03 | | EINECS: | | | Product Categories: | Heterocycle-Pyridine series | | Mol File: | Mol File |  |
| | 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Chemical Properties |
| Boiling point | 335.0±42.0 °C(Predicted) | | density | 1.692±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 3.48±0.10(Predicted) | | Appearance | White to off-white Solid |
| | 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | 5-Bromo-4-methyl-2-vinylpyridine (600 mg, 3 mmol) was used as raw material and dissolved in a solvent mixture of acetone-water (1:1, 54 mL). Subsequently, potassium permanganate (KMnO4, 957 mg, 6 mmol) was added to this solution. The reaction mixture was stirred at room temperature for 3 days. Upon completion of the reaction, the mixture was filtered to remove insoluble impurities, and the filtrate was concentrated and purified by column chromatography to give 5-bromo-4-methylpyridine-2-carboxylic acid (700 mg, 92% yield) as a white solid. | | References | [1] Patent: US2011/71150, 2011, A1. Location in patent: Page/Page column 33-34
[2] Patent: US2013/158040, 2013, A1. Location in patent: Paragraph 0134
[3] Patent: US2013/158049, 2013, A1. Location in patent: Paragraph 0168
[4] Patent: US2013/158066, 2013, A1. Location in patent: Paragraph 0134
[5] Patent: WO2012/143329, 2012, A1 |
| | 5-BROMO-4-METHYL-PYRIDINE-2-CARBOXYLIC ACID Preparation Products And Raw materials |
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