(S)-UFR2709
| 中文名称 | (S)-UFR2709 |
|---|---|
| 中文同义词 | |
| 英文名称 | 2-Pyrrolidinemethanol, 1-methyl-, 2-benzoate, (2S)- |
| 英文同义词 | 2-Pyrrolidinemethanol, 1-methyl-, 2-benzoate, (2S)-;(S)-UFR2709;(2S)?-1-?Methyl-?2-?pyrrolidinemethanol 2-?Benzoate;Benzoic acid [(2S)-1-methylpyrrolidine-2-yl]methyl ester |
| CAS号 | 1431628-22-6 |
| 分子式 | C13H17NO2 |
| 分子量 | 219.28 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1431628-22-6.mol |
| 结构式 |  |
(S)-UFR2709 性质
| 沸点 | 304.4±15.0 °C(Predicted) |
|---|---|
| 密度 | 1.079±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 9.47±0.40(Predicted) |
Brain nicotinic acetylcholine receptors (nAChRs) is a heterogeneous family of pentameric acetylcholine-gated cation channels, which is a molecular target for the treatment of alcohol abuse and dependence.
(S)-UFR2709 (50-100 μg/ml; 3 min and then maintained for another 5 min in a holding tank before testing the swimming behaviour in the test tank for a period of 5 min) produces a decrease in the bottom dwelling for NTT test, and UFR2709 induces a significant and dose-dependent decrease in bottom dwelling time to 52.9 and 87.0 s, respectively at 50 and 100 μg/ml.(S)-UFR2709 (50-100 μg/ml) decreases nicotine-evoked mRNA expression of α4 nACh receptor subunit, but UFR2709 has less effect on α4 nACh receptor subunit in the brain of adult zebrafish.(S)-UFR2709 (intraperitoneal injection; 1-10 mg/kg; daily; 17 days) reduces ethanol consumption and ethanol preference and increased water consumption in a dose-dependent manner. The most effective dose of UFR2709 is 2.5 mg/kg, it induces a 56% reduction in alcohol consumption. (S)-UFR2709 does not affect the weight or locomotor activity of the rats.
| Animal Model: | High-alcohol-drinking UChB rats |
| Dosage: | 10 mg/kg, 5 mg/kg, 2.5 mg/kg, or 1 mg/kg |
| Administration: | Intraperitoneal injection; 1-10 mg/kg; daily; 17 days |
| Result: | Did not affect the weight or locomotor activity and reduced ethanol consumption and preference. |